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TKIM

CAS No. 326921-25-9

TKIM( —— )

Catalog No. M22546 CAS No. 326921-25-9

TKIM is a TWIK-related potassium channel 1 (TREK-1) inhibitor, binding to the pocket of the intermediate (IM) state of TREK-1.TKIM binds to the pocket of the IM state of TREK-1, which differs from the binding of common inhibitors, which bind to channels in the inactive state.

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
Size Price / USD Stock Quantity
1 mL x 10 mM in DMSO 88 In Stock
5MG 82 In Stock
10MG 126 In Stock
25MG 224 In Stock
50MG 308 In Stock
100MG 412 In Stock
200MG 554 In Stock
500MG Get Quote In Stock
1G Get Quote In Stock
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Biological Information

  • Product Name
    TKIM
  • Note
    Research use only, not for human use.
  • Brief Description
    TKIM is a TWIK-related potassium channel 1 (TREK-1) inhibitor, binding to the pocket of the intermediate (IM) state of TREK-1.TKIM binds to the pocket of the IM state of TREK-1, which differs from the binding of common inhibitors, which bind to channels in the inactive state.
  • Description
    TKIM is a TWIK-related potassium channel 1 (TREK-1) inhibitor, binding to the pocket of the intermediate (IM) state of TREK-1.TKIM binds to the pocket of the IM state of TREK-1, which differs from the binding of common inhibitors, which bind to channels in the inactive state. Overall, identified an allosteric ligand-binding site and a new mechanistic inhibitor for TREK-1, suggesting that IM states of ion channels may be promising druggable targets for use in discovering allosteric modulators.
  • In Vitro
    ——
  • In Vivo
    ——
  • Synonyms
    ——
  • Pathway
    Cell Cycle/DNA Damage
  • Target
    Potassium Channel
  • Recptor
    TREK-1
  • Research Area
    ——
  • Indication
    ——

Chemical Information

  • CAS Number
    326921-25-9
  • Formula Weight
    371.05
  • Molecular Formula
    C18H14ClN3O2S?
  • Purity
    >98% (HPLC)
  • Solubility
    In Vitro:?DMSO : 250 mg/mL (672.33 mM)
  • SMILES
    Clc1ccc(cc1)C(=O)NNC(=O)CSc1ccc2ccccc2n1
  • Chemical Name
    ——

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1.Ma Y , Luo Q , Fu J , et al. Discovery of an Inhibitor for the TREK-1 Channel Targeting an Intermediate Transition State of Channel Gating[J]. Journal of Medicinal Chemistry, 2020.
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