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Home - Products - GPCR/G Protein - S1P Receptor - TY-52156

TY-52156

CAS No. 934369-14-9

TY-52156( —— )

Catalog No. M22470 CAS No. 934369-14-9

TY-52156 is an effective and selective S1P3 receptor antagonist (Ki: 110 nM). TY-52156 displays submicromolar potency and a high degree of selectivity for the S1P3 receptor.

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
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Biological Information

  • Product Name
    TY-52156
  • Note
    Research use only, not for human use.
  • Brief Description
    TY-52156 is an effective and selective S1P3 receptor antagonist (Ki: 110 nM). TY-52156 displays submicromolar potency and a high degree of selectivity for the S1P3 receptor.
  • Description
    TY-52156 is an effective and selective S1P3 receptor antagonist (Ki: 110 nM). TY-52156 displays submicromolar potency and a high degree of selectivity for the S1P3 receptor. TY-52156 inhibits the S1P3 receptor-dependent increase in [Ca2+]i. TY-52156 (10 μM; 10 min) inhibits S1P-induced p44/p42 MAPK phosphorylation.After oral administration in vivo, TY-52156 (10 mg/kg, 30 mg/kg; p.o.) inhibits S1P3 receptor-induced bradycardia.
  • In Vitro
    Western Blot Analysis Cell Line:Chinese hamster ovary K1 cells Concentration:10 μM Incubation Time:10 min Result:Inhibited S1P-induced p44/p42 MAPK phosphorylation.
  • In Vivo
    Animal Model:Male SD rats (290–340 g)Dosage:10 mg/kg, 30 mg/kg Administration:Oral administration Result:Inhibited S1P3 receptor-induced bradycardia after oral administration in vivo.
  • Synonyms
    ——
  • Pathway
    GPCR/G Protein
  • Target
    S1P Receptor
  • Recptor
    S1P3
  • Research Area
    ——
  • Indication
    ——

Chemical Information

  • CAS Number
    934369-14-9
  • Formula Weight
    364.27
  • Molecular Formula
    C18H19Cl2N3O
  • Purity
    >98% (HPLC)
  • Solubility
    DMSO:100 mg/mL (274.52 mM)
  • SMILES
    CC(C)(C)C(=O)C(\NNc1ccc(Cl)cc1)=N\c1ccc(Cl)cc1
  • Chemical Name
    ——

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1. Murakami A, et al. Sphingosine 1-phosphate (S1P) regulates vascular contraction via S1P3 receptor: investigation based on a new S1P3 receptor antagonist. Mol Pharmacol. 2010 Apr;77(4):704-13.
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