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LCH-7749944
CAS No. 796888-12-5
LCH-7749944( GNF-PF-2356 )
Catalog No. M22466 CAS No. 796888-12-5
LCH-7749944 effectively suppresses the proliferation of human gastric cancer cells through downregulation of PAK4/c-Src/EGFR/cyclin D1 pathway and induces apoptosis.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 1 mL x 10 mM in DMSO | 112 | In Stock |
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| 5MG | 105 | In Stock |
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| 10MG | 159 | In Stock |
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| 25MG | 283 | In Stock |
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| 50MG | 416 | In Stock |
|
| 100MG | 603 | In Stock |
|
| 200MG | 812 | In Stock |
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| 500MG | Get Quote | In Stock |
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| 1G | Get Quote | In Stock |
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Biological Information
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Product NameLCH-7749944
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NoteResearch use only, not for human use.
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Brief DescriptionLCH-7749944 effectively suppresses the proliferation of human gastric cancer cells through downregulation of PAK4/c-Src/EGFR/cyclin D1 pathway and induces apoptosis.
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DescriptionLCH-7749944 effectively suppresses the proliferation of human gastric cancer cells through downregulation of PAK4/c-Src/EGFR/cyclin D1 pathway and induces apoptosis. LCH-7749944 is a potent PAK4 inhibitor with an IC50 of 14.93 μM. LCH-7749944 (5-20 μM; 12-48 hours) prominently induces a dose-dependent increase in the percentage of cells in G1 phase and decrease in S phase. LCH-7749944 (5-30 μM; 24 hours) dramatically decreases levels of phosphoPAK4, phospho-c-Src, phospho-EGFR and cyclin D1 protein expression in a dose-dependent manner. LCH-7749944 (GNF-PF-2356; 5-50 μM; 24 hours) inhibits the proliferation of MKN-1, BGC823, SGC7901 and MGC803 cells in a concentration dependent manner. LCH-7749944 (5-20 μM; 12-48 hours) induces apoptosis of SGC7901 cells.
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In VitroCell Proliferation Assay Cell Line:MKN-1, BGC823, SGC7901 and MGC803 human gastric cancer cells Concentration:5, 10, 15, 20, 25, 30, 35, 40, 45, 50 μM Incubation Time:24 hoursResult:Inhibited the proliferation of MKN-1, BGC823, SGC7901 and MGC803 cells in a concentration dependent manner.Apoptosis Analysis Cell Line:SGC7901 cells Concentration:5, 10, 20 μM Incubation Time:12, 24, 48 hours Result:Induced apoptosis of SGC7901 cells.Cell Cycle Analysis Cell Line:SGC7901 cells Concentration:5, 10, 20 μM Incubation Time:12, 24, 48 hours Result:Prominently induced a dose-dependent increase in the percentage of cells in G1 phase and decrease in S phase.Western Blot AnalysisCell Line:SGC7901 cells Concentration:5, 10, 20, 30 μM Incubation Time:24 hours Result:Dramatically decreased levels of phosphoPAK4, phospho-c-Src, phospho-EGFR and cyclin D1 protein expression in a dose-dependent manner.
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In Vivo——
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SynonymsGNF-PF-2356
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PathwayApoptosis
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TargetApoptosis
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RecptorPAK4|apoptosis
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Research Area——
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Indication——
Chemical Information
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CAS Number796888-12-5
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Formula Weight350.41
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Molecular FormulaC20H22N4O2
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Purity>98% (HPLC)
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SolubilityDMSO:250 mg/mL (713.45 mM; Need ultrasonic)
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SMILESCOc1cccc(Nc2nc(NCC3CCCO3)c3ccccc3n2)c1
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Chemical Name——
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1. Zhang J, et al. LCH-7749944, a novel and potent p21-activated kinase 4 inhibitor, suppresses proliferation and invasion in human gastric cancer cells. Cancer Lett. 2012 Apr 1;317(1):24-32.
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