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Home - Products - Metabolic Enzyme/Protease - Dehydrogenase - DHODH-IN-11

DHODH-IN-11

CAS No. 1263303-95-2

DHODH-IN-11( —— )

Catalog No. M22430 CAS No. 1263303-95-2

DHODH-IN-11 is a leflunomide derivative and weak dihydroorotate dehydrogenase (DHODH) inhibitor with a pKa of 5.03.A compound structurally related to leflunomide was designed, which contained furan ring (compound 14a).

Purity : >98% (HPLC)

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Biological Information

  • Product Name
    DHODH-IN-11
  • Note
    Research use only, not for human use.
  • Brief Description
    DHODH-IN-11 is a leflunomide derivative and weak dihydroorotate dehydrogenase (DHODH) inhibitor with a pKa of 5.03.A compound structurally related to leflunomide was designed, which contained furan ring (compound 14a).
  • Description
    DHODH-IN-11 is a leflunomide derivative and weak dihydroorotate dehydrogenase (DHODH) inhibitor with a pKa of 5.03.A compound structurally related to leflunomide was designed, which contained furan ring (compound 14a). Compound 14a undergoes 4 ring cleavage under physiological pH conditions to obtain the corresponding cyanooxime DHODH-IN-11 (compound 14b). DHODH-IN-14 has been analyzed as a DHODH inhibitor; its inefficiency may be due to the unfavorable stereochemistry of the oxime substructure.
  • In Vitro
    Designed a compound structurally related to Leflunomide, containing the furazan ring (Compound 14a), is designed. Compound 14a undergo ring 4 scission under physiological pH conditions to afford the corresponding cyano-oximes DHODH-IN-11 (Compound 14b). DHODH-IN-14 has been assayed as a DHODH inhibitor; its low potency is probably due to the unfavourable stereochemistry of the oxime substructure.
  • In Vivo
    ——
  • Synonyms
    ——
  • Pathway
    Metabolic Enzyme/Protease
  • Target
    Dehydrogenase
  • Recptor
    DHODH
  • Research Area
    ——
  • Indication
    ——

Chemical Information

  • CAS Number
    1263303-95-2
  • Formula Weight
    265.27
  • Molecular Formula
    C15H11N3O2
  • Purity
    >98% (HPLC)
  • Solubility
    In Vitro:?DMSO : 125 mg/mL (471.22 mM)
  • SMILES
    O\N=C(/C#N)C(=O)Nc1ccc(cc1)-c1ccccc1
  • Chemical Name
    ——

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1. Giorgis M, et al. 1,2,5-Oxadiazole analogues of leflunomide and related compounds. Eur J Med Chem. 2011 Jan;46(1):383-92.
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