Compound 35( —— )

Catalog No. M22414 CAS No. ——

Compounds 35 are superior inhibitors of Ebola (Mayinga) and Marburg (Angola) infectious viruses.Compounds 35 are superior inhibitors of Ebola (Mayinga) and Marburg (Angola) infectious viruses. Compounds 35 have shown good metabolic stability in plasma and liver microsomes (rat and human), and 32 did not inhibit CYP3A4 nor CYP2C9.

Purity : >98% (HPLC)

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Biological Information

Product Name

Compound 35
Note

Research use only, not for human use.
Brief Description

Compounds 35 are superior inhibitors of Ebola (Mayinga) and Marburg (Angola) infectious viruses.Compounds 35 are superior inhibitors of Ebola (Mayinga) and Marburg (Angola) infectious viruses. Compounds 35 have shown good metabolic stability in plasma and liver microsomes (rat and human), and 32 did not inhibit CYP3A4 nor CYP2C9.
Description

Compounds 35 are superior inhibitors of Ebola (Mayinga) and Marburg (Angola) infectious viruses.Compounds 35 are superior inhibitors of Ebola (Mayinga) and Marburg (Angola) infectious viruses. Compounds 35 have shown good metabolic stability in plasma and liver microsomes (rat and human), and 32 did not inhibit CYP3A4 nor CYP2C9. These 4-(aminomethyl)benzamides are suitable for further optimization as inhibitors of filovirus entry, with potential to be developed as therapeutic agents for the treatment and control of Ebola virus infections.
In Vitro

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In Vivo

——
Synonyms

——
Pathway

Others
Target

Other Targets
Recptor

Ebola (Mayinga)| Marburg (Angola)
Research Area

——
Indication

——

Chemical Information

CAS Number

——
Formula Weight

461.52
Molecular Formula

C25H30F3N3O2
Purity

>98% (HPLC)
Solubility

——
SMILES

FC(F)(F)c2cc(ccc2N1CCC(C)CC1)NC(=O)c3ccc(cc3)CN4CCOCC4
Chemical Name

——

Shipping & Storage Information

Storage

(-20℃)
Shipping

With Ice Pack
Stability

≥ 2 years

Reference

1.Gaisina I N , Peet N P , Wong L , et al. Discovery and Structural Optimization of 4-(Aminomethyl)benzamides as Potent Entry Inhibitors of Ebola and Marburg Virus Infections[J]. Journal of Medicinal Chemistry, 2020,

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