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Zoliflodacin (b)

CAS No. 1245732-48-2

Zoliflodacin (b)( —— )

Catalog No. M22412 CAS No. 1245732-48-2

Zoliflodacin is a new antibiotic that inhibits DNA biosynthesis.

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
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Biological Information

  • Product Name
    Zoliflodacin (b)
  • Note
    Research use only, not for human use.
  • Brief Description
    Zoliflodacin is a new antibiotic that inhibits DNA biosynthesis.
  • Description
    Zoliflodacin is a new antibiotic that inhibits DNA biosynthesis.
  • In Vitro
    ——
  • In Vivo
    Animal Model:MCF-7 human breast cancers growing in miceDosage:56 mg/kg Administration:IV; 2 daily; 49 days Result:Alone was able to produce significant (>50%) tumor regression. This regression was stabilized when combined with daily dosing with the oral HDAC4 inhibitor, Tasquinimod (10 mg/kg/d; oral).Animal Model:BALB/c miceDosage:67 mg/kg (Pharmacokinetic Analysis)Administration:IV; a single dose Result:Had a half-life of 4.9 hours.
  • Synonyms
    ——
  • Pathway
    Others
  • Target
    Other Targets
  • Recptor
    Others
  • Research Area
    ——
  • Indication
    ——

Chemical Information

  • CAS Number
    1245732-48-2
  • Formula Weight
    1409.5
  • Molecular Formula
    C66H100N6O27?
  • Purity
    >98% (HPLC)
  • Solubility
    ——
  • SMILES
    CCCCCCCC(=O)O[C@H]1[C@H]2C(=C([C@@H]1OC(=O)/C(=C\C)/C)C)[C@H]3[C@]([C@H](C[C@]2(C)OC(=O)C)OC(=O)CCCCCCCCCCCNC(=O)C[C@@H](C(=O)N[C@@H](CCC(=O)N[C@@H](CCC(=O)N[C@@H](CCC(=O)N[C@@H](CCC(=O)O)C(=O)O)C(=O)O)C(=O)O)C(=O)O)N)([C@](C(=O)O3)(C)O)O
  • Chemical Name
    ——

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1. Taylor S N , Marrazzo J , Batteiger B E , et al. Single-Dose Zoliflodacin (ETX0914) for Treatment of Urogenital Gonorrhea[J]. New England Journal of Medicine, 2018, 379(19):1835-1845.
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