Edetic acid

Research use only, not for human use.

Edetic acid is a chelating agent commonly used in protein purification, both to eliminate contaminating divalent cations and to inhibit protease activity.

Edetic acid is a chelating agent commonly used in protein purification, both to eliminate contaminating divalent cations and to inhibit protease activity.

——

Animal Model: Male Wistar rat model of cirrhosis induced by CCl4Dosage:60 mg/kg, 120 mg/kg, 240 mg/kg Administration: Intraperitoneal injection (i.p.); Three times per week for 3 weeks (during this period, CCl4 administration continued). After CCl4 and mineral oil mixture treatment (200 μL/mouse; i.p.; Three times per week for eight weeks).Result:Kept kept all the rats alive at the 60 mg/kg dose, but died at 120 and 240 mg/kg.Reduced fibrosis of the liver in surviving rats (20%).Animal Model:Male Wistar rat model of cirrhosis induced by CCl Dosage:60 mg/kg Administration:Intraperitoneal injection (i.p.); Three times per week for 11 weeks. EDTA and CCl4 were administered during 11 weeks, three times per week on alternate days). Intraperitoneal injection (i.p.); Three times per week. After CCl4 treatment (i.p.; Three times per week for eight weeks) (Therapeutic EDTA group: EDTA and CCl4 were administered for 3 weeks, three times per week on alternate days).Result:Increased sod activity by 50% in the preventive EDTA group. (Compared with untreated EDTA group)Increased Cp activity in the preventive EDTA (30%) and therapeutic EDTA (20%) groups. (Compared with the fibrotic group).Decreased mRNA expression of the pro-inflammatory molecule (TNF-α and LI-6) and the profibrogenic molecules (TGF-β and αCOLI) in both the prevention and treatment groups.

Ethylenediaminetetraacetic acid,EDTA

Others

Other Targets

Others

——

——

60-00-4

292.24

C10H16N2O8

>98% (HPLC)

In Vitro:?0.1 M NaOH : 6.67 mg/mL (22.8)

OC(=O)CN(CCN(CC(O)=O)CC(O)=O)CC(O)=O

——

(-20℃)

With Ice Pack

≥ 2 years