ASTX029( ASTX-029 )

Catalog No. M22011 CAS No. 2095719-92-7

COA

Datasheet

HNMR

HPLC

MSDS

Handing Instructions

Get Quotation Bulk Inquiry Add to Cart

Product Name

ASTX029
Note

Research use only, not for human use.
Brief Description

ASTX029 is a selective and orally bioavailable extracellular signal-regulated kinases 1 and 2 (ERK 1/2) inhibitor, with potential antineoplastic activity.
Description

ASTX029 is a selective and orally bioavailable extracellular signal-regulated kinases 1 and 2 (ERK 1/2) inhibitor, with potential antineoplastic activity.
In Vitro

Western Blot Analysis Cell Line:A375 and HCT116 cells Concentration:1 nM-100 nM Incubation Time:2 h Result:Decreased pRSK and pERK.Apoptosis Analysis Cell Line:A375 and HCT116 cells Concentration:0-100 nM Incubation Time:0-72 h Result:Arrested cell in the G1-phase.Increased cleaved PARP and Bim protein level.
In Vivo

Animal Model:Colo205, A375, Calu-6, HCC44, HCT116 or MA-MEL-28 xenografts tumor-bearing mice Dosage:75 mg/kg Administration:p.o., once daily Result:Inhibited tumor growth in various tumor models.
Synonyms

ASTX-029
Pathway

MAPK/ERK Signaling
Target

ERK
Recptor

ERK1/2
Research Area

——
Indication

——

CAS Number

2095719-92-7
Formula Weight

584.04
Molecular Formula

C29H31ClFN5O5
Purity

>98% (HPLC)
Solubility

DMSO：98 mg/mL (167.8 mM); Ethanol:48 mg/mL (82.2 mM)
SMILES

COC1=CC(F)=CC(=C1)[C@@H](CO)NC(=O)[C@@H](C)N1CC2=CC=C(C=C2C1=O)C1=NC(NC2CCOCC2)=NC=C1Cl
Chemical Name

——