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UC-514321
CAS No. 299420-83-0
UC-514321( UC514321 )
Catalog No. M13922 CAS No. 299420-83-0
UC-514321 is a more effective analog of NSC-370284 that directly binds to STAT3/5.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 1 mL x 10 mM in DMSO | 170 | In Stock |
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| 5MG | 155 | In Stock |
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| 10MG | 250 | In Stock |
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| 25MG | 503 | In Stock |
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| 50MG | 737 | In Stock |
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| 100MG | 1107 | In Stock |
|
| 200MG | 1516 | In Stock |
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| 500MG | Get Quote | In Stock |
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| 1G | Get Quote | In Stock |
|
Biological Information
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Product NameUC-514321
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NoteResearch use only, not for human use.
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Brief DescriptionUC-514321 is a more effective analog of NSC-370284 that directly binds to STAT3/5.
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DescriptionUC-514321 is a more effective analog of NSC-370284 that directly binds to STAT3/5, significantly and selectively suppresses the viability of AML cells with high level of TET1 expression both in vitro and in vivo; shows no inhibitory effect on the viability of TET1-low AML (i.e., NB4) cells, function as TET1-transcription inhibitor in TET1-high AMLs and the anti-leukemic effects are TET1-dependent.
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In VitroCell Viability Assay Cell Line:MONOMAC-6, THP-1, KOCL-48, KASUMI-1, ML-2, and NB4 cells.Concentration:0-500 nM.Incubation Time:48 hours.Result:Most significantly repressed MONOMAC-6 cell viability. Showed no inhibitory effect on the viability of TET1-low AML.RT-PCR Cell Line:MONOMAC-6 cells.Concentration:0-500 nM.Incubation Time:48 hours.Result:Functioned as TET1-transcription inhibitors in TET1-high AMLs and their anti-leukemic effects are TET1-dependent.
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In VivoAnimal Model:MLL-AF9-AML mice and AE9a-AML model.Dosage:2.5 mg/kg.Administration:IP., once per day, for 10 days. Result:Showed an improved therapeutic effect in AML mouse models in vivo. Prolonged the median survival over three fold.
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SynonymsUC514321
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PathwayJAK/STAT Signaling
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TargetSTAT
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RecptorSTAT
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Research Area——
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Indication——
Chemical Information
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CAS Number299420-83-0
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Formula Weight441.568
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Molecular FormulaC26H35NO5
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Purity>98% (HPLC)
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SolubilityIn Vitro:?Ethanol : 50 mg/mL (113.23 mM)
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SMILES——
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Chemical Name6-((3,5-di-tert-butyl-4-hydroxyphenyl)(morpholino)methyl)benzo[d][1,3]dioxol-5-ol
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1. Jiang X, et al. Nat Commun. 2017 Dec 13;8(1):2099.
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