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SX-682

CAS No. 1648843-04-2

SX-682( —— )

Catalog No. M21976 CAS No. 1648843-04-2

SX-682 is a potent, selective and orally bioavailable inhibitor of CXCR1/2 ,has the potential to treat castration-resistant prostate cancer.

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
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Biological Information

  • Product Name
    SX-682
  • Note
    Research use only, not for human use.
  • Brief Description
    SX-682 is a potent, selective and orally bioavailable inhibitor of CXCR1/2 ,has the potential to treat castration-resistant prostate cancer.
  • Description
    SX-682 is a potent, selective and orally bioavailable inhibitor of CXCR1/2 ,has the potential to treat castration-resistant prostate cancer.SX-682 significantly inhibited trafficking of PMN-MDSCs without altering CXCR2 ligand expression. Trafficking of CXCR1+ macrophages was unaltered, possibly due to coexpression of CSF1R. Reduced PMN-MDSC tumor infiltration correlated with enhanced accumulation of endogenous or adoptively transferred T cells. Accordingly, tumor growth inhibition or the rate of established tumor rejection following programed death-axis (PD-axis) immune checkpoint blockade or adoptive cell transfer of engineered T cells was enhanced in combination with SX-682.
  • In Vitro
    ——
  • In Vivo
    Animal Model:C57BL/6NTac-Tyrtm1Arte?female mice Dosage:50 mg/kg Administration:Orally; twice a day on a Monday through Friday Result:Has Meager to moderate effects on CRPC progression.
  • Synonyms
    ——
  • Pathway
    Autophagy
  • Target
    CXCR
  • Recptor
    CXCR1|CXCR2
  • Research Area
    Cancer
  • Indication
    Melanoma Stage IiiMelanoma Stage Iv

Chemical Information

  • CAS Number
    1648843-04-2
  • Formula Weight
    467.2
  • Molecular Formula
    C19H14BF4N3O4S
  • Purity
    >98% (HPLC)
  • Solubility
    DMSO:250 mg/mL (535.10 mM; Need ultrasonic)
  • SMILES
    OB(O)c1ccc(OC(F)(F)F)cc1CSc1ncc(cn1)C(=O)Nc1ccc(F)cc1
  • Chemical Name
    ——

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1. Sun L , Clavijo P E , Robbins Y , et al. Inhibiting myeloid-derived suppressor cell trafficking enhances T cell immunotherapy[J]. 2019.2. Lu X, et al. Effective combinatorial immunotherapy for castration-resistant prostate cancer. Nature. 2017 Mar 30;543(7647):728-732.
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