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TED-347
CAS No. 2378626-29-8
TED-347( —— )
Catalog No. M21960 CAS No. 2378626-29-8
TED-347 is an irreversible and covalent inhibitor of TEAD4-Yap1 protein-protein interaction(EC50 of 5.9 μM), and inhibits glioblastoma cell viability.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 1 mL x 10 mM in DMSO | 93 | In Stock |
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| 5MG | 110 | In Stock |
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| 10MG | 155 | In Stock |
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| 25MG | 312 | In Stock |
|
| 50MG | 461 | In Stock |
|
| 100MG | 662 | In Stock |
|
| 200MG | Get Quote | In Stock |
|
| 500MG | Get Quote | In Stock |
|
| 1G | Get Quote | In Stock |
|
Biological Information
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Product NameTED-347
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NoteResearch use only, not for human use.
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Brief DescriptionTED-347 is an irreversible and covalent inhibitor of TEAD4-Yap1 protein-protein interaction(EC50 of 5.9 μM), and inhibits glioblastoma cell viability.
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DescriptionTED-347 is an irreversible and covalent inhibitor of TEAD4-Yap1 protein-protein interaction(EC50 of 5.9 μM), and inhibits glioblastoma cell viability.
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In VitroCell Viability Assay Cell Line:GBM43 glioblastoma cell lines Concentration:0.5, 1, 10, 100 μM Incubation Time:48 hoursResult:Inhibited GBM43 cancer cell viability and inhibited GBM43 cell viability by 30% at 10 μM.Western Blot Analysis Cell Line:HEK-293 cells Concentration:5 μM Incubation Time:48 hours Result:Showed a significant loss of co-immunoprecipitation of Myc-tagged TEAD4 with FLAG-tagged Yap1.RT-PCRCell Line:HEK-293 cells Concentration:10 μM Incubation Time:48 hours Result:Showed a significant reduction in CTGF transcript levels versus control cells and had no inhibition on TEAD mutant transcriptional activity and protein-protein interactions in cell culture.
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In Vivo——
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Synonyms——
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PathwayOthers
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TargetOther Targets
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RecptorTEAD4-Yap1
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Research Area——
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Indication——
Chemical Information
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CAS Number2378626-29-8
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Formula Weight313.7
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Molecular FormulaC15H11ClF3NO
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Purity>98% (HPLC)
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SolubilityDMSO:64 mg/ml(204.02 mM)
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SMILESFC(F)(F)c1cccc(Nc2ccccc2C(=O)CCl)c1
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Chemical Name——
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1.Khuchtumur Bum-Erdene, et al. Small-Molecule Covalent Modification of Conserved Cysteine Leads to Allosteric Inhibition of the TEAD?Yap Protein-Protein Interaction. Cell Chem Biol. 2019 Mar 21;26(3):378-389.e13.
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