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QO-40
CAS No. 1259536-70-3
QO-40( —— )
Catalog No. M21936 CAS No. 1259536-70-3
QO-40 is a KCNQ2/3 potassium channels activator.QO-40 potently augmented KCNQ2/3 channels expressed in Chinese hamster ovary cells and shifted the half-maximal activation voltage (V(1/2)) in the hyperpolarizing direction. The V(1/2) was negatively shifted in a concentration-dependent manner.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 1 mL x 10 mM in DMSO | 29 | In Stock |
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| 25MG | 48 | In Stock |
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| 50MG | 70 | In Stock |
|
| 100MG | 105 | In Stock |
|
| 200MG | 155 | In Stock |
|
| 500MG | Get Quote | In Stock |
|
| 1G | Get Quote | In Stock |
|
Biological Information
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Product NameQO-40
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NoteResearch use only, not for human use.
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Brief DescriptionQO-40 is a KCNQ2/3 potassium channels activator.QO-40 potently augmented KCNQ2/3 channels expressed in Chinese hamster ovary cells and shifted the half-maximal activation voltage (V(1/2)) in the hyperpolarizing direction. The V(1/2) was negatively shifted in a concentration-dependent manner.
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DescriptionQO-40 is a KCNQ2/3 potassium channels activator.QO-40 potently augmented KCNQ2/3 channels expressed in Chinese hamster ovary cells and shifted the half-maximal activation voltage (V(1/2)) in the hyperpolarizing direction. The V(1/2) was negatively shifted in a concentration-dependent manner. The compounds markedly slowed both KCNQ2/3 channel activation and deactivation kinetics.
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In Vitro——
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In Vivo——
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Synonyms——
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PathwayCell Cycle/DNA Damage
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TargetPotassium Channel
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RecptorKCNQ2/Q3 potassium channel
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Research Area——
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Indication——
Chemical Information
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CAS Number1259536-70-3
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Formula Weight377.75
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Molecular FormulaC18H11ClF3N3O
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Purity>98% (HPLC)
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Solubility——
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SMILESFC(F)(F)c1nn4C(=O)C=C(Nc4c1c3cccc2ccccc23)CCl
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Chemical Name——
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1.Jia C , Qi J , Zhang F , et al. Activation of KCNQ2/3 Potassium Channels by Novel Pyrazolo[1,5-a]pyrimidin-7(4H)-One Derivatives[J]. Pharmacology, 2011, 87(5-6):297-310.
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