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Home - Products - Cell Cycle/DNA Damage - Potassium Channel - QO-40

QO-40

CAS No. 1259536-70-3

QO-40( —— )

Catalog No. M21936 CAS No. 1259536-70-3

QO-40 is a KCNQ2/3 potassium channels activator.QO-40 potently augmented KCNQ2/3 channels expressed in Chinese hamster ovary cells and shifted the half-maximal activation voltage (V(1/2)) in the hyperpolarizing direction. The V(1/2) was negatively shifted in a concentration-dependent manner.

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
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Biological Information

  • Product Name
    QO-40
  • Note
    Research use only, not for human use.
  • Brief Description
    QO-40 is a KCNQ2/3 potassium channels activator.QO-40 potently augmented KCNQ2/3 channels expressed in Chinese hamster ovary cells and shifted the half-maximal activation voltage (V(1/2)) in the hyperpolarizing direction. The V(1/2) was negatively shifted in a concentration-dependent manner.
  • Description
    QO-40 is a KCNQ2/3 potassium channels activator.QO-40 potently augmented KCNQ2/3 channels expressed in Chinese hamster ovary cells and shifted the half-maximal activation voltage (V(1/2)) in the hyperpolarizing direction. The V(1/2) was negatively shifted in a concentration-dependent manner. The compounds markedly slowed both KCNQ2/3 channel activation and deactivation kinetics.
  • In Vitro
    ——
  • In Vivo
    ——
  • Synonyms
    ——
  • Pathway
    Cell Cycle/DNA Damage
  • Target
    Potassium Channel
  • Recptor
    KCNQ2/Q3 potassium channel
  • Research Area
    ——
  • Indication
    ——

Chemical Information

  • CAS Number
    1259536-70-3
  • Formula Weight
    377.75
  • Molecular Formula
    C18H11ClF3N3O
  • Purity
    >98% (HPLC)
  • Solubility
    ——
  • SMILES
    FC(F)(F)c1nn4C(=O)C=C(Nc4c1c3cccc2ccccc23)CCl
  • Chemical Name
    ——

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1.Jia C , Qi J , Zhang F , et al. Activation of KCNQ2/3 Potassium Channels by Novel Pyrazolo[1,5-a]pyrimidin-7(4H)-One Derivatives[J]. Pharmacology, 2011, 87(5-6):297-310.
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