Cart
sales@molnova.com
Home - Products - Others - Other Targets - NS-3-008 HCl

NS-3-008 HCl

CAS No. 1172854-54-4

NS-3-008 HCl( —— )

Catalog No. M21935 CAS No. 1172854-54-4

NS-3-008 HCl is a transcriptional G0/G1 switch 2 (G0s2) inhibitor( IC50 of 2.25 μM).Administration of NS-3-008 inhibited the expression of G0s2 in healthy mice liver.

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
Size Price / USD Stock Quantity
2MG 36 Get Quote
5MG 58 Get Quote
10MG 87 Get Quote
25MG 158 Get Quote
50MG 266 Get Quote
100MG 399 Get Quote
200MG Get Quote Get Quote
500MG Get Quote Get Quote
1G Get Quote Get Quote
Get Quotation Bulk Inquiry Add to Cart

Biological Information

  • Product Name
    NS-3-008 HCl
  • Note
    Research use only, not for human use.
  • Brief Description
    NS-3-008 HCl is a transcriptional G0/G1 switch 2 (G0s2) inhibitor( IC50 of 2.25 μM).Administration of NS-3-008 inhibited the expression of G0s2 in healthy mice liver.
  • Description
    NS-3-008 HCl is a transcriptional G0/G1 switch 2 (G0s2) inhibitor( IC50 of 2.25 μM).Administration of NS-3-008 inhibited the expression of G0s2 in healthy mice liver. In contrast, administration of NS-3-008 did not affect the MBP in wild-type sham and 5/6Nx mice. NS-3-008 as a novel G0s2 inhibitor and showed that administration of this inhibitor ameliorated renal dysfunction in wild-type 5/6Nx mice.
  • In Vitro
    NS-3-008 binds to Hsd17b4; knockdown of Hsd17b4 decreased G0s2 mRNA levels, whereas overexpression of Hsd17b4 induced G0s2 mRNA expression. The inhibitory effects of NS-3-008 are blocked by knockdown of Hsd17b4 or deletion of the Stat5 binding site in the G0s2 promoter. NS-3-008 decreases the nuclear phosphorylation of Stat5.
  • In Vivo
    NS-3-008 (5 mg/kg; oral administration; daily; for 4 weeks; wild-type 5/6Nx mice) treatment results in decreased levels of G0s2 and Ccl2 mRNA in the kidneys. The phosphorylation of Stat5 and p65 protein is decreased, and SUN concentrations and renal caspase 3/7 activity decreased in 5/6Nx mice treated with NS-03-08. The F4/80-positive area and F4/80 protein levels are decreased in 5/6Nx mice treated with NS-3-008.
  • Synonyms
    ——
  • Pathway
    Others
  • Target
    Other Targets
  • Recptor
    G0s2
  • Research Area
    ——
  • Indication
    ——

Chemical Information

  • CAS Number
    1172854-54-4
  • Formula Weight
    269.81
  • Molecular Formula
    C14H24ClN3
  • Purity
    >98% (HPLC)
  • Solubility
    DMSO:120 mg/ml(444.76 mM; Need ultrasonic);H2O : 125 mg/mL (463.29 mM; Need ultrasonic)
  • SMILES
    Cl.CCCCCCNC(=N)NCc1ccccc1
  • Chemical Name
    ——

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1.Matsunaga N, et al. Inhibition of G0/G1 Switch 2 Ameliorates Renal Inflammation in Chronic Kidney Disease. EBioMedicine. 2016 Nov;13:262-273.
Calculator

Molecular Weight Calculator

Dilution Calculator

Molarity Calculator

molnova catalog
related products

  • Ecabapide

    Ecabapide (DQ-2511) is a novel gastrointestinal motility promoter that significantly enhances gastric emptying in SHRSP.Ecabapide activates cyclic GMP-dependent housekeeping Cl- channels in rabbit gastric wall cells.

  • OD1

    Potent rat Nav1.7, human Nav1.4 and rat Nav1.6 channel activator (EC50 values are 7, 10 and 47 nM, respectively). Exhibits minimal activation at mammalian Nav1.2, Nav1.3 and Nav1.5 (EC50 values >3 μM). Inhibits fast inactivation on all channels. Increases peak currents at all voltages and stimulates a persistent Na+ current at hNav1.7 channel. Increases hyperpolarization at Nav1.4 and Nav1.6 channels. Induces spontaneous pain in vivo.

  • Melanotan I

    Melanotan-I has the amino acid sequence of Ser-Tyr-Ser-Nle-Glu-His-D-Phe-Arg-Trp-Gly-Lys-Pro-Val and a molecular weight of 1647.4 Dalton.

Sign In Join Free