Cart
sales@molnova.com
Home - Products - Others - Other Targets - Hyperforin dicyclohexylammonium salt

Hyperforin dicyclohexylammonium salt

CAS No. 238074-03-8

Hyperforin dicyclohexylammonium salt( Hyperforin DCHA )

Catalog No. M21824 CAS No. 238074-03-8

Hyperforin dicyclohexylammonium salt (Hyperforin DCHA) is a transient receptor canonical 6 (TRPC6) channels activator.

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
Size Price / USD Stock Quantity
5MG 370 In Stock
50MG 1431 In Stock
100MG 2187 In Stock
200MG Get Quote In Stock
500MG Get Quote In Stock
1G Get Quote In Stock
Get Quotation Bulk Inquiry Add to Cart

Biological Information

  • Product Name
    Hyperforin dicyclohexylammonium salt
  • Note
    Research use only, not for human use.
  • Brief Description
    Hyperforin dicyclohexylammonium salt (Hyperforin DCHA) is a transient receptor canonical 6 (TRPC6) channels activator.
  • Description
    Hyperforin dicyclohexylammonium salt (Hyperforin DCHA) is a transient receptor canonical 6 (TRPC6) channels activator. Hyperforin dicyclohexylammonium salt modulates Ca2+ levels by activating Ca2+-conducting non-selective canonical TRPC6 channels. Hyperforin dicyclohexylammonium salt shows antidepressant effect.
  • In Vitro
    Western Blot Analysis Cell Line:HaCaT cells Concentration:0.1, 1, 10 μM; with or without 10, 20 ng/mL TNF-α Incubation Time:2 hours Result:Reduced the expressions of p-p38, p-ERK, p-JNK, and p-STAT3, especially at the dosage of 10 μM.
  • In Vivo
    Animal Model:IMQ-induced psoriasis-like mice modelDosage:5 mg/kg Administration:Intraperitoneal injection; once daily for 7 days Result:Significantly ameliorated skin lesion throughout the treatment period, demonstrated by the reduced severity score of skin inflammation.Suppressed infiltration of CD3+ T cells and down regulated expression of Il1, Il6, Il23, Il17a, Il22, antimicrobial peptides (AMPs) in the skin lesion.
  • Synonyms
    Hyperforin DCHA
  • Pathway
    Others
  • Target
    Other Targets
  • Recptor
    ——
  • Research Area
    ——
  • Indication
    ——

Chemical Information

  • CAS Number
    238074-03-8
  • Formula Weight
    718.1
  • Molecular Formula
    C??H??NO?
  • Purity
    >98% (HPLC)
  • Solubility
    DMSO : 50 mg/mL (69.63 mM; Need ultrasonic)
  • SMILES
    CC(C)C([C@@]12[C@@](C)([C@H](C[C@](C/C=C(C)/C)(C(C(C/C=C(C)/C)=C2O)=O)C1=O)C/C=C(C)/C)CC/C=C(C)/C)=O.C3(CCCCC3)NC4CCCCC4
  • Chemical Name
    ——

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1. Heiser JH, et al. TRPC6 channel-mediated neurite outgrowth in PC12 cells and hippocampal neurons involves activation of RAS/MEK/ERK, PI3K, and CAMKIV signaling. J Neurochem. 2013 Nov;127(3):303-13. 2. Pochwat B, et al. Hyperforin Potentiates Antidepressant-Like Activity of Lanicemine in Mice. Front Mol Neurosci. 2018 Dec 12;11:456.
Calculator

Molecular Weight Calculator

Dilution Calculator

Molarity Calculator

molnova catalog
related products

  • 1H-Purine-2,6-dione

    TH5427 hydrochloride is a potent, selective NUDT5 inhibitor (IC50=29 nM). TH5427 hydrochloride shows an apparent 690-fold selectivity for NUDT5 over MTH1. TH5427 hydrochloride blocks progestin-dependent, PAR-derived nuclear ATP synthesis and subsequent chromatin remodeling, gene regulation and proliferation in breast cancer cells.

  • SARS-CoV-2 Mpro-IN-9

    SARS-CoV-2 Mpro-IN-9 (compound c7), a nonpeptidic, noncovalent inhibitor of SARS-CoV-2 main protease (Mpro), exhibits potent inhibitory action (IC50 = 0.085 μM) and improved physicochemical and drug metabolism and pharmacokinetics (DMPK) properties.

  • 10-Hydroxydecanoic A...

    It has antibacterial, anti - cancer and anti - radiation activity.

Sign In Join Free