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Home - Products - Immunology/Inflammation - TLR - TLR4-IN-C34

TLR4-IN-C34

CAS No. 40592-88-9

TLR4-IN-C34( —— )

Catalog No. M21768 CAS No. 40592-88-9

TLR4-IN-C34 is an orally active TLR4 inhibitor and reduces systemic inflammation in models of endotoxemia and necrotizing enterocolitis.

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
Size Price / USD Stock Quantity
1 mL x 10 mM in DMSO 65 In Stock
2MG 36 In Stock
5MG 58 In Stock
10MG 81 In Stock
25MG 126 In Stock
50MG 200 In Stock
100MG 296 In Stock
200MG Get Quote In Stock
500MG Get Quote In Stock
1G Get Quote In Stock
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Biological Information

  • Product Name
    TLR4-IN-C34
  • Note
    Research use only, not for human use.
  • Brief Description
    TLR4-IN-C34 is an orally active TLR4 inhibitor and reduces systemic inflammation in models of endotoxemia and necrotizing enterocolitis.
  • Description
    TLR4-IN-C34 is an orally active TLR4 inhibitor and reduces systemic inflammation in models of endotoxemia and necrotizing enterocolitis.
  • In Vitro
    ——
  • In Vivo
    TLR4-IN-C34 (C34, 1 mg/kg, orally daily) could attenuate NEC severity and demonstrates a marked preservation of the intestinal mucosa. Animal Model:Experimental NEC induced in 7-8 day old mice.Dosage:1 mg/kg.Administration:Orally every morning.Result:Attenuated intestinal inflammation.
  • Synonyms
    ——
  • Pathway
    Immunology/Inflammation
  • Target
    TLR
  • Recptor
    ——
  • Research Area
    ——
  • Indication
    ——

Chemical Information

  • CAS Number
    40592-88-9
  • Formula Weight
    389.4
  • Molecular Formula
    C??H??NO?
  • Purity
    >98% (HPLC)
  • Solubility
    DMSO : 250 mg/mL (642.01 mM; Need ultrasonic)
  • SMILES
    O=C(N[C@H]([C@@H](OC(C)=O)[C@H](OC(C)=O)[C@@H](COC(C)=O)O1)[C@H]1OC(C)C)C
  • Chemical Name
    ——

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1. Neal MD, et al. Discovery and validation of a new class of small molecule Toll-like receptor 4 (TLR4) inhibitors. PLoS One. 2013 Jun 12;8(6):e65779. 2. Wipf P, et al. Synthesis of anti-inflammatory α-and β-linked acetamidopyranosides as inhibitors of toll-like receptor 4 (TLR4). Tetrahedron Lett. 2015 Jun 3;56(23):3097-3100.
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