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ABR-238901
CAS No. 1638200-22-2
ABR-238901( —— )
Catalog No. M35093 CAS No. 1638200-22-2
ABR-238901 is an oral, active S100A8/A9 blocker that inhibits the interaction of S100A8/A9 with its receptors RAGE(receptor for advanced glycation end products) and TLR4 (toll-like receptor 4). ABR-238901 has potential as a compound for the treatment of myocardial infarction (MI).
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 1 mL x 10 mM in DMSO | 328 | In Stock |
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| 5MG | 297 | In Stock |
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| 10MG | 472 | In Stock |
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| 25MG | 749 | In Stock |
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| 50MG | 1004 | In Stock |
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| 100MG | 1376 | In Stock |
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| 200MG | Get Quote | In Stock |
|
| 500MG | Get Quote | In Stock |
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| 1G | Get Quote | In Stock |
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Biological Information
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Product NameABR-238901
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NoteResearch use only, not for human use.
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Brief DescriptionABR-238901 is an oral, active S100A8/A9 blocker that inhibits the interaction of S100A8/A9 with its receptors RAGE(receptor for advanced glycation end products) and TLR4 (toll-like receptor 4). ABR-238901 has potential as a compound for the treatment of myocardial infarction (MI).
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DescriptionABR-238901 is an orally active and potent S100A8/A9 blocker and inhibits S100A8/A9 interaction with its receptors RAGE (receptor for advanced glycation endproducts) and TLR4 (toll-like receptor 4). ABR-238901 has the potential for myocardial infarction (MI) research.
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In Vitro——
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In VivoAnimal Model:C57BL/KaLwRij mice with 5T33MMvv cells Dosage:30 mg/kg Administration:Gavage; daily; for 3 weeks Result:Caused less angiogenesis.Caused less IL6 and IL10 in myeloid-derived suppressor cells (MDSCs).
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Synonyms——
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PathwayImmunology/Inflammation
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TargetTLR
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RecptorTLR
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Research Area——
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Indication——
Chemical Information
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CAS Number1638200-22-2
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Formula Weight394.63
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Molecular FormulaC11H9BrClN3O4S
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Purity>98% (HPLC)
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SolubilityIn Vitro:?DMSO : 33.33 mg/mL (84.46 mM; Ultrasonic (<60°C); H2O : < 0.1 mg/mL (insoluble)
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SMILESCOc1ncc(cc1Br)S(=O)(=O)Nc1cncc(Cl)c1O
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Chemical Name——
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
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CU-T12-9
CU-T12-9 is a potent TLR1/2 agonist(EC50 of 52.9 nM in HEK-Blue hTLR2 SEAP assay).?It acts by activating the NFkB pathway, upregulating proinflammatory cytokines, and enhancing TLR1 and TLR2 dimerization.CU-T12-9 activates both the innate and the adaptive immune systems.
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Loxoribine
Loxoribine is a guanosine analog. Loxoribine is an orally bioavailable and selective Toll-like receptor (TLR) 7 agonist. It has anti-viral and anti-tumor activities.Loxoribine is a potent new immunostimulant with a relatively broad spectrum of immunobiological activities.
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ODN 1826
ODN 1826 is a 20-mer DNA strand, a TLR9 agonist and an immunostimulant, with anti-tumor and cardioprotective effects, promoting apoptosis, and stimulating the production of NO and iNOS. ODN 1826 is a CpG DNA mimetic that can be used as an adjuvant for synthetic vaccines.
