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Vonafexor

CAS No. 1192171-69-9

Vonafexor( EYP001 )

Catalog No. M21752 CAS No. 1192171-69-9

Vonafexor (EYP001) is a selective FXR agonist with anti-HBV effects.

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
Size Price / USD Stock Quantity
1 mL x 10 mM in DMSO 29 In Stock
10MG 42 In Stock
25MG 88 In Stock
50MG 137 In Stock
100MG 230 In Stock
200MG Get Quote In Stock
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Biological Information

  • Product Name
    Vonafexor
  • Note
    Research use only, not for human use.
  • Brief Description
    Vonafexor (EYP001) is a selective FXR agonist with anti-HBV effects.
  • Description
    Vonafexor (EYP001) is a selective FXR agonist with anti-HBV effects.(In Vitro):Vonafexor (EYP001) inhibits the HBV replication cycle in HepaRG cells resulting in significant reductions in HBV DNA, HBsAg and HBeAg secretion, with additive effects when combined with Entecavir (HY-13623) or Tenofovir (HY-13910).
  • In Vitro
    Vonafexor (EYP001) inhibits the HBV replication cycle in HepaRG cells resulting in significant reductions in HBV DNA, HBsAg and HBeAg secretion, with additive effects when combined with Entecavir (HY-13623) or Tenofovir (HY-13910).
  • In Vivo
    ——
  • Synonyms
    EYP001
  • Pathway
    Metabolic Enzyme/Protease
  • Target
    FXR
  • Recptor
    ——
  • Research Area
    ——
  • Indication
    ——

Chemical Information

  • CAS Number
    1192171-69-9
  • Formula Weight
    489.76
  • Molecular Formula
    C??H??Cl?N?O?S
  • Purity
    >98% (HPLC)
  • Solubility
    DMSO : 83.33 mg/mL (170.14 mM; Need ultrasonic)
  • SMILES
    O=C(C1=CC2=C(Cl)C(N3CCN(S(=O)(C4=C(Cl)C=CC=C4Cl)=O)CC3)=CC=C2O1)O
  • Chemical Name
    ——

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1. Joly S, et al. The selective FXR agonist EYP001 is well tolerated in healthy subjects and has additive anti-HBV effect with nucleoside analogues in HepaRG cells. J Hepatol 66(1):S690. 2. Fiorucci S,et al. Bile acid modulators for the treatment of nonalcoholic steatohepatitis (NASH) [published online ahead of print, 2020 Jun 19]. Expert Opin Investig Drugs. 2020;1-10.
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