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Home - Products - Cell Cycle/DNA Damage - GPR - AR 231453

AR 231453

CAS No. 733750-99-7

AR 231453( —— )

Catalog No. M21652 CAS No. 733750-99-7

AR 231453 is a selective and orally available GPR119 agonistcan stimulate β-cell replication and improve islet graft function.

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
Size Price / USD Stock Quantity
1 mL x 10 mM in DMSO 68 In Stock
5MG 60 In Stock
10MG 92 In Stock
25MG 150 In Stock
50MG 212 In Stock
100MG 330 In Stock
200MG Get Quote In Stock
500MG Get Quote In Stock
1G Get Quote In Stock
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Biological Information

  • Product Name
    AR 231453
  • Note
    Research use only, not for human use.
  • Brief Description
    AR 231453 is a selective and orally available GPR119 agonistcan stimulate β-cell replication and improve islet graft function.
  • Description
    AR 231453 is a selective and orally available GPR119 agonistcan stimulate β-cell replication and improve islet graft function.
  • In Vitro
    AR 231453 is inactive at all other GPCRs tested (more than 230, including all known pancreatic islet receptors), indicating that it is highly selective for GPR119.AR 231453 potently stimulats cAMP accumulation (EC50 = 4.7 nM) with a maximal efficacy similar to that seen with forskolin. AR 231453 significantly enhances insulin release in HIT-T15 cells, with an EC50 of 3.5 nM.AR 231453 also stimulates insulin release in isolated mouse islets at glucose concentrations ranging from 8-17 mM.
  • In Vivo
    AR231453 (20 mg/kg, orally) markedly improves oral glucose tolerance in a dose-dependent fashion, with efficacy similar to maximally effective doses of the sulfonylurea glyburide. Animal Model:Mice.Dosage:20 mg/kg. Administration:Orally, once.Result:Improved glucose tolerance in mice.
  • Synonyms
    ——
  • Pathway
    Cell Cycle/DNA Damage
  • Target
    GPR
  • Recptor
    GPR119
  • Research Area
    ——
  • Indication
    ——

Chemical Information

  • CAS Number
    733750-99-7
  • Formula Weight
    505.52
  • Molecular Formula
    C21H24FN7O5S
  • Purity
    >98% (HPLC)
  • Solubility
    DMSO:60 mg/mL (118.69 mM);H2O:60 mg/mL (118.69 mM; Need ultrasonic and warming)
  • SMILES
    CC(C)c1noc(n1)C1CCN(CC1)c1ncnc(Nc2ccc(cc2F)S(C)(=O)=O)c1[N+]([O-])=O
  • Chemical Name
    N-(2-fluoro-4-methanesulfonylphenyl)-(6-[4-(3-isopropyl-[124]oxadiazol-5-yl)-piperidin-1-yl]-5-nitropyrimidin-4-yl)amine

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1.Chu ZL et al. A role for intestinal endocrine cell-expressed g protein-coupled receptor 119 in glycemic control by enhancing glucagon-like Peptide-1 and glucose-dependent insulinotropic Peptide release. Endocrinology. 2008 May;149(5):2038-47.
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