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AR 231453
CAS No. 733750-99-7
AR 231453( —— )
Catalog No. M21652 CAS No. 733750-99-7
AR 231453 is a selective and orally available GPR119 agonistcan stimulate β-cell replication and improve islet graft function.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 1 mL x 10 mM in DMSO | 68 | In Stock |
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| 5MG | 60 | In Stock |
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| 10MG | 92 | In Stock |
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| 25MG | 150 | In Stock |
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| 50MG | 212 | In Stock |
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| 100MG | 330 | In Stock |
|
| 200MG | Get Quote | In Stock |
|
| 500MG | Get Quote | In Stock |
|
| 1G | Get Quote | In Stock |
|
Biological Information
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Product NameAR 231453
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NoteResearch use only, not for human use.
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Brief DescriptionAR 231453 is a selective and orally available GPR119 agonistcan stimulate β-cell replication and improve islet graft function.
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DescriptionAR 231453 is a selective and orally available GPR119 agonistcan stimulate β-cell replication and improve islet graft function.
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In VitroAR 231453 is inactive at all other GPCRs tested (more than 230, including all known pancreatic islet receptors), indicating that it is highly selective for GPR119.AR 231453 potently stimulats cAMP accumulation (EC50 = 4.7 nM) with a maximal efficacy similar to that seen with forskolin. AR 231453 significantly enhances insulin release in HIT-T15 cells, with an EC50 of 3.5 nM.AR 231453 also stimulates insulin release in isolated mouse islets at glucose concentrations ranging from 8-17 mM.
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In VivoAR231453 (20 mg/kg, orally) markedly improves oral glucose tolerance in a dose-dependent fashion, with efficacy similar to maximally effective doses of the sulfonylurea glyburide. Animal Model:Mice.Dosage:20 mg/kg. Administration:Orally, once.Result:Improved glucose tolerance in mice.
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Synonyms——
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PathwayCell Cycle/DNA Damage
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TargetGPR
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RecptorGPR119
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Research Area——
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Indication——
Chemical Information
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CAS Number733750-99-7
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Formula Weight505.52
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Molecular FormulaC21H24FN7O5S
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Purity>98% (HPLC)
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SolubilityDMSO:60 mg/mL (118.69 mM);H2O:60 mg/mL (118.69 mM; Need ultrasonic and warming)
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SMILESCC(C)c1noc(n1)C1CCN(CC1)c1ncnc(Nc2ccc(cc2F)S(C)(=O)=O)c1[N+]([O-])=O
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Chemical NameN-(2-fluoro-4-methanesulfonylphenyl)-(6-[4-(3-isopropyl-[124]oxadiazol-5-yl)-piperidin-1-yl]-5-nitropyrimidin-4-yl)amine
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1.Chu ZL et al. A role for intestinal endocrine cell-expressed g protein-coupled receptor 119 in glycemic control by enhancing glucagon-like Peptide-1 and glucose-dependent insulinotropic Peptide release. Endocrinology. 2008 May;149(5):2038-47.
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