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STING agonist-1
CAS No. 702662-50-8
STING agonist-1( G10 )
Catalog No. M21625 CAS No. 702662-50-8
STING agonist-1 is a human-specific STING agonistelicits antiviral activity against emerging Alphaviruses.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 2MG | 40 | Get Quote |
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| 5MG | 65 | Get Quote |
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| 10MG | 97 | Get Quote |
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| 25MG | 185 | Get Quote |
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| 50MG | 332 | Get Quote |
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| 100MG | 494 | Get Quote |
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| 200MG | Get Quote | Get Quote |
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| 500MG | Get Quote | Get Quote |
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| 1G | Get Quote | Get Quote |
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Biological Information
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Product NameSTING agonist-1
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NoteResearch use only, not for human use.
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Brief DescriptionSTING agonist-1 is a human-specific STING agonistelicits antiviral activity against emerging Alphaviruses.
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DescriptionSTING agonist-1 is a human-specific STING agonistelicits antiviral activity against emerging Alphaviruses.
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In VitroG10 induces IFN/IRF3- but not NF-κB-dependent transcription in human fibroblasts.G10 is an indirect activator of human STING-dependent phenotypes.G10-mediated IRF3 activation and anti-Alphaviral activity occur independently of IPS-1/MAVS-dependent signaling.STING is required for G10-mediated IRF3 activation, gene expression, and anti-Alphaviral activity.G10 induces STING-dependent synthesis and secretion of bioactive interferon.G10 induces innate antiviral mRNA expression in primary human cells.
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In Vivo——
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SynonymsG10
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PathwayImmunology/Inflammation
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TargetSTING
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RecptorSTING
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Research Area——
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Indication——
Chemical Information
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CAS Number702662-50-8
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Formula Weight430.88
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Molecular FormulaC21H16ClFN2O3S
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Purity>98% (HPLC)
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SolubilityDMSO:100 mg/mL (232.08 mM; Need ultrasonic)
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SMILESFc1cccc(Cl)c1CN1C(=O)CSc2ccc(cc12)C(=O)NCc1ccco1
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Chemical Name4-(2-Chloro-6-fluorobenzyl)-N-(furan-2-ylmethyl)-3-oxo-34-dihydro-2H-benzo[b][14]thiazine-6-carboxamide
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1.Sali TM et al. Characterization of a Novel Human-Specific STING Agonist that Elicits Antiviral Activity Against Emerging Alphaviruses. PLoS Pathog. 2015 Dec 8;11(12):e1005324.
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