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ASP7663
CAS No. 1190217-35-6
ASP7663( —— )
Catalog No. M21597 CAS No. 1190217-35-6
ASP7663 is a TRPA1 Receptor Agonist and exhibiting an abdominal analgesic effect in vivo.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 1 mL x 10 mM in DMSO | 79 | In Stock |
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| 5MG | 71 | In Stock |
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| 10MG | 107 | In Stock |
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| 25MG | 218 | In Stock |
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| 50MG | 324 | In Stock |
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| 100MG | 486 | In Stock |
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| 200MG | Get Quote | In Stock |
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| 500MG | Get Quote | In Stock |
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| 1G | Get Quote | In Stock |
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Biological Information
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Product NameASP7663
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NoteResearch use only, not for human use.
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Brief DescriptionASP7663 is a TRPA1 Receptor Agonist and exhibiting an abdominal analgesic effect in vivo.
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DescriptionASP7663 is a TRPA1 Receptor Agonist and exhibiting an abdominal analgesic effect in vivo.
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In VitroASP7663 concentration dependently increases intracellular Ca2+ concentration in human, rat, and mouse TRPA1 expressed in HEK293 cells in a similar manner, with respective EC50 values (95% confidence interval [CI]) of 0.51 (0.40–0.66), 0.54 (0.41–0.72), and 0.50 (0.41–0.63) μmol/L.ASP7663 concentration-dependently stimulates 5-HT release from QGP-1 cells, a lineage of TRPA1-expressing EC cells, with an EC50 value of 72.5 (52.6–99.9) μmol/L.
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In VivoASP7663 significantly improves the loperamide-induced delay in colonic transit in mice. ASP7663 (orally, 0.3 and 1 mg/kg) significantly shortens the prolonged bead expulsion time caused by loperamide.ASP7663 (orally, 1 and 3 mg/kg) exhibits inhibitory effects on colorectal distension in rat. Animal Model:CRD model (colorectal distension in rat).Dosage:1 and 3 mg/kg.Administration:Orally.Result:Significantly reduced the number of abdominal contractions evoked during CRD at pressures of 30, 45, and 60 mmHg. ASP7663 also reduced the number of abdominal contractions by intravenous treatment.
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Synonyms——
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PathwayMembrane Transporter/Ion Channel
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TargetTRP/TRPV Channel
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RecptorTRPA1
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Research Area——
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Indication——
Chemical Information
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CAS Number1190217-35-6
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Formula Weight263.26
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Molecular FormulaC14H14FNO3?
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Purity>98% (HPLC)
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SolubilityIn Vitro:?DMSO : 50 mg/mL (189.93 mM)
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SMILESCC(C)CN1C(=O)\C(=C\C(O)=O)c2cccc(F)c12
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Chemical Name(2E)-2-[7-Fluoro-12-dihydro-1-(2-methylpropyl)-2-oxo-3H-indol-3-ylidene]acetic acid
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
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Capsazepine
Capsazepine is an antagonist of TRPV1 receptor ( IC50 : 562 nM).?Capsazepine blocks the painful sensation of heat caused by capsaicin (the active ingredient of chilli pepper) which activates the TRPV1 ion channel.?It is therefore considered to be a capsaicin antagonist.
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EIPA
EIPA (L593754, MH 12-43) is a TRPP3 channel inhibitor (IC50: 10.5 μM). It also inhibits Na+/H+-exchanger (NHE) and macropinocytosis.It is found that EIPA, benzamil, and phenamil rapidly and reversibly block Ca2+-activated TRPP3 channel activation at -50 mV, with IC50s of 143, 10.5, 1.1, and 0.14 μM, respectively.
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Adenosine 5-diphosph...
Adenosine 5'-diphosphoribose sodium (ADP ribose sodium) is a metabolite of nicotinamide adenine nucleotide (NAD+), which is widely present in organisms.
