L-(+)-Ergothioneine( Ergothioneine )

Catalog No. M21510 CAS No. 497-30-3

COA

Datasheet

HNMR

HPLC

MSDS

Handing Instructions

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Product Name

L-(+)-Ergothioneine
Note

Research use only, not for human use.
Brief Description

Ergothioneine is synthesized by certain bacteria and fungi. It is generally considered an antioxidant.
Description

Ergothioneine is synthesized by certain bacteria and fungi. It is generally considered an antioxidant.
In Vitro

Cell Viability Assay Cell Line:PC12 Concentration:0.25, 1 mM Incubation Time:23 h Result:Increased cell viability by approximately 13% and 34%, respectively.Western Blot Analysis Cell Line:PC12 Concentration:0.25, 1 mM Incubation Time:23 h Result:Counteracted the p38 phosphorylation induced by 1 h incubation with H2O2.
In Vivo

Animal Model:Cisplatin-treated ratsDosage:70 mg/kg Administration:p.o.Result:Decreased serum creatinine and BUN.Increased GFR at two-fold.Suppressed cisplatin-induced oxidative stress and GCT.Up-regulated the levels of Nrf2, NQO1, and HO-1. Suppresses NF-κB signaling and the pro-inflammatory cytokines.
Synonyms

Ergothioneine
Pathway

Others
Target

Antioxidant
Recptor

Antioxidant
Research Area

——
Indication

——

CAS Number

497-30-3
Formula Weight

229.3
Molecular Formula

C9H15N3O2S
Purity

>98% (HPLC)
Solubility

H2O:125 mg/mL (545.14 mM; Need ultrasonic)
SMILES

C[N+](C)(C)[C@@H](Cc1c[nH]c(=S)[nH]1)C([O-])=O
Chemical Name

(S)-3-(2-thioxo-23-dihydro-1H-imidazol-4-yl)-2-(trimethylammonio)propanoate

1.Oumari M et al. Regeneration of ergothioneine after reaction with singlet oxygen. Free Radic Biol Med. 2019 Apr;134:498-504.

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