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Home - Products - GPCR/G Protein - Calcium Channel - JTV-519 hydrochloride

JTV-519 hydrochloride

CAS No. 1038410-88-6

JTV-519 hydrochloride( K201 | JTV519 )

Catalog No. M10192 CAS No. 1038410-88-6

JTV-519 (K201) is a Ca2+-dependent blocker of SERCA and a partial agonist of ryanodine receptors (RyRs).

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
Size Price / USD Stock Quantity
1 mL x 10 mM in DMSO 129 In Stock
5MG 106 In Stock
10MG 149 In Stock
25MG 247 In Stock
50MG 358 In Stock
100MG 533 In Stock
200MG Get Quote In Stock
500MG 1163 In Stock
1G Get Quote In Stock
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Biological Information

  • Product Name
    JTV-519 hydrochloride
  • Note
    Research use only, not for human use.
  • Brief Description
    JTV-519 (K201) is a Ca2+-dependent blocker of SERCA and a partial agonist of ryanodine receptors (RyRs).
  • Description
    JTV-519 (K201) is a Ca2+-dependent blocker of SERCA and a partial agonist of ryanodine receptors (RyRs); displays Ca(2+)-dependent inhibition of SERCA-dependent ATPase activity with IC50 of 9 uM at 0.25 Ca2+ in cardiac muscle; may prevent abnormal Ca(2+) leak from the sarcoplasmic reticulum (SR) in the ischemic heart and skeletal muscle (SkM) by stabilizing the ryanodine receptors (RyRs; RyR1 and RyR2, respectively).Heart Arrhythmia Phase 2 Discontinued.
  • In Vitro
    ——
  • In Vivo
    Animal Model:Wild type male C57BL/6 mice weighing 18-22g with polymicrobial sepsis produced by cecal ligation and puncture (CLP) Dosage:0.5 mg/kg/h Administration:Applied intraperitoneally 2 h before the surgery Result:Improved cardiac function, where the EF and FS were significantly increased.
  • Synonyms
    K201 | JTV519
  • Pathway
    GPCR/G Protein
  • Target
    Calcium Channel
  • Recptor
    Calcium Channel
  • Research Area
    Cardiovascular Disease
  • Indication
    Heart Arrhythmia

Chemical Information

  • CAS Number
    1038410-88-6
  • Formula Weight
    461.061
  • Molecular Formula
    C25H33ClN2O2S
  • Purity
    >98% (HPLC)
  • Solubility
    ——
  • SMILES
    C1CC(CCN1CCC(=O)N1Cc2c(SCC1)ccc(c2)OC)Cc1ccccc1.Cl
  • Chemical Name
    1-(2,3-Dihydro-7-methoxy-1,4-benzothiazepin-4(5H)-yl)-3-[4-(phenylmethyl)-1-piperidinyl]-1-propanone hydrochloride

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1. Darcy YL, et al. Mol Pharmacol. 2016 Aug;90(2):106-15. 2. Inagaki K, et al. Circulation. 2000 Feb 22;101(7):797-804. 3. Ito K, et al. Br J Pharmacol. 2000 Jun;130(4):767-76. 4. Nakaya H, et al. Br J Pharmacol. 2000 Dec;131(7):1363-72.
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