3-Methyl-L-histidine

Research use only, not for human use.

3-Methylhistidine belongs to the class of organic compounds known as histidine and derivatives. Histidine and derivatives are compounds containing cysteine or a derivative thereof resulting from reaction of cysteine at the amino group or the carboxy group or from the replacement of any hydrogen of glycine by a heteroatom.

3-Methylhistidine belongs to the class of organic compounds known as histidine and derivatives. Histidine and derivatives are compounds containing cysteine or a derivative thereof resulting from reaction of cysteine at the amino group or the carboxy group or from the replacement of any hydrogen of glycine by a heteroatom. It is also a biomarker for the consumption of soy products. 3-Methylhistidine is a very strong basic compound (based on its pKa). 3-Methylhistidine exists in all eukaryotes ranging from yeast to humans. In humans 3-methylhistidine is involved in methylhistidine metabolism. 3-Methylhistidine with regard to humans has been found to be associated with several diseases such as diabetes mellitus type 2 eosinophilic esophagitis and kidney disease; 3-methylhistidine has also been linked to the inborn metabolic disorder propionic acidemia. The measurement of 3-methylhistidine provides an index of the rate of muscle protein breakdown. 3-Methylhistidine is a product of peptide bond synthesis and methylation of actin and myosin. 3-Methylhistidine is a biomarker for meat consumption especially chicken.

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Proteasome/Ubiquitin

Endogenous Metabolite

Human Endogenous Metabolite

Metabolic Disease

Intestinal Diseases

368-16-1

169.18

C7H11N3O2

>98% (HPLC)

In Vitro:?H2O : 100 mg/mL (591.09 mM)

Cn1c(C[C@@H](C(O)=O)N)cnc1

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(-20℃)

With Ice Pack

≥ 2 years