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PBD-150
CAS No. 790663-33-1
PBD-150( —— )
Catalog No. M21163 CAS No. 790663-33-1
PBD-150 is an inhibitor of human glutaminyl cyclase (hQC) Y115E-Y117E variant( ki : 490 nM).
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 1 mL x 10 mM in DMSO | 62 | In Stock |
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| 2MG | 33 | In Stock |
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| 5MG | 53 | In Stock |
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| 10MG | 86 | In Stock |
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| 25MG | 174 | In Stock |
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| 50MG | 253 | In Stock |
|
| 100MG | 377 | In Stock |
|
| 200MG | Get Quote | In Stock |
|
| 500MG | Get Quote | In Stock |
|
| 1G | Get Quote | In Stock |
|
Biological Information
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Product NamePBD-150
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NoteResearch use only, not for human use.
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Brief DescriptionPBD-150 is an inhibitor of human glutaminyl cyclase (hQC) Y115E-Y117E variant( ki : 490 nM).
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DescriptionPBD-150 is an inhibitor of human glutaminyl cyclase (hQC) Y115E-Y117E variant( ki : 490 nM).
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In Vitro——
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In VivoPBD-150 is able to reduce the deposition of pyroglutamate-modified amyloid-β peptides in brain of transgenic mouse models of Alzheimer disease, leading to a significant improvement of learning and memory in those transgenic animals.
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Synonyms——
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PathwayMembrane Transporter/Ion Channel
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TargetBeta Amyloid
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Recptorglutaminyl cyclase (hQC) Y115E-Y117E
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Research Area——
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Indication——
Chemical Information
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CAS Number790663-33-1
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Formula Weight320.4
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Molecular FormulaC15H20N4O2S
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Purity>98% (HPLC)
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SolubilityDMSO:125 mg/mL (390.13 mM; Need ultrasonic)
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SMILESCOc1ccc(NC(=S)NCCCn2ccnc2)cc1OC
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Chemical Name——
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
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Lecanemab
Lecanemab (BAN-2401) is an IgG1 monoclonal antibody targeting soluble aggregated β-amyloid (Abeta) with activity against oligomers, protofibrils, and insoluble protofibrils, and may be useful in the study of Alzheimer's disease (AD)-induced mild cognitive impairment and mild AD dementia.
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β-Amyloid 29-40
β-Amyloid (29-40) is a fragment of Amyloid-β peptide.Alzheimer's beta amyloid peptide (29-40/42) C-terminal fragments have physical and chemical properties related to those of fusion peptides of viral proteins. The fusion of liposomes can be induced by these peptides in vitro.
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β-Amyloid 13-27
β-Amyloid (13-27) is a peptide consisting of amino acid of 13 to 27 of beta amyloid protein. This synthetic peptide consists of amino acids 26 to 40 of beta amyloid protein. It can be used to study the kinetics of beta amyloid formation.
