Astrophloxine

CAS No. 14696-39-0

Astrophloxine( —— )

Catalog No. M35727 CAS No. 14696-39-0

Astrophloxine is a fluorescent imaging probe that targets antiparallel dimers and can be used to detect aggregated Aβ in brain tissue and cerebrospinal fluid samples from Alzheimer's disease (AD) mice.

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
Size Price / USD Stock Quantity
1 mL x 10 mM in DMSO 28 In Stock
100MG 35 In Stock
200MG Get Quote In Stock
500MG 83 In Stock
1G Get Quote In Stock

Biological Information

  • Product Name
    Astrophloxine
  • Note
    Research use only, not for human use.
  • Brief Description
    Astrophloxine is a fluorescent imaging probe that targets antiparallel dimers and can be used to detect aggregated Aβ in brain tissue and cerebrospinal fluid samples from Alzheimer's disease (AD) mice.
  • Description
    Astrophloxine is a fluorescent imaging probe capable of targeting antiparallel dimers. Astrophloxine can be used to detect aggregated Aβ in brain tissue and cerebrospinal fluid samples of Alzheimer's disease (AD) mice.
  • In Vitro
    Astrophloxine binds Aβ dimers with stronger fluorescence intensity (A.U.) than binding Aβ monomers.Protocol for CSF analyses:1.Prepare 1 μL of CSF samples with 1 μL of 10X protease inhibitors and diluted the mixture with 8 μL of binding buffer. Binding buffer (0.1 M sodium phosphate, 0.15 M sodium chloride, 10 mM EDTA; pH 7.2).2.Dilute Astrophloxine to 0.5 μM with binding buffer.3.Add individual samples and dye to the wells of a 96-well half-area black microplate with a sample to dye ratio of 1:3.
  • In Vivo
    Astrophloxine shows more fluorescence (A.U.) in APP/PS1 mice CSF rather in WT mice, and is able to indicate soluble Aβ oligomers in CSF and insoluble plaques in brain tissue.
  • Synonyms
    ——
  • Pathway
    Membrane Transporter/Ion Channel
  • Target
    Beta Amyloid
  • Recptor
    Beta Amyloid
  • Research Area
    ——
  • Indication
    ——

Chemical Information

  • CAS Number
    14696-39-0
  • Formula Weight
    512.47
  • Molecular Formula
    C27H33IN2
  • Purity
    >98% (HPLC)
  • Solubility
    ——
  • SMILES
    [I-].CCN1\C(=C\C=C\C2=[N+](CC)c3ccccc3C2(C)C)C(C)(C)c2ccccc12
  • Chemical Name
    ——

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1. Lee JC, et al. Discovery of Chemicals to Either Clear or Indicate Amyloid Aggregates by Targeting Memory-Impairing Anti-Parallel Aβ Dimers. Angew Chem Int Ed Engl. 2020 Jul 6;59(28):11491-11500.? ?
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