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Methotrexate disodium
CAS No. 7413-34-5
Methotrexate disodium( —— )
Catalog No. M21160 CAS No. 7413-34-5
Methotrexate disodium is an tetrahydrofolate dehydrogenase inhibitor.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 50MG | 32 | In Stock |
|
| 100MG | 45 | In Stock |
|
| 200MG | 59 | In Stock |
|
| 500MG | 119 | In Stock |
|
| 1G | Get Quote | In Stock |
|
Biological Information
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Product NameMethotrexate disodium
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NoteResearch use only, not for human use.
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Brief DescriptionMethotrexate disodium is an tetrahydrofolate dehydrogenase inhibitor.
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DescriptionMethotrexate disodium is an tetrahydrofolate dehydrogenase inhibitor.(In Vivo):Methotrexate (Amethopterin) disodium reduces thymus and spleen indices of mice. Methotrexate disodium markedly decreases white blood cells, thymic and splenic lymphocytes at dose ≥5 mg/kg. However, there is a significant difference between the treatment plus control group and the model group (p<0.01). The combination of grape seed proanthocyanidins and Siberian ginseng eleutherosides obviously diminishes the effects of Methotrexate exposure on indices of thymus and spleens in mice.Methotrexate (MTX) disodium (2 mg/kg; i.p.; once in a week for 5 weeks) is effective in Freund's complete adjuvant-induced arthritis. The combination of Methotrexate disodium (1 mg/kg; i.p.; once in a week for 5 weeks) and Curcumin (30 mg/kg and 100 mg/kg, thrice a week for 5 weeks; i.p.) shows a significant anti-arthritic action and protection from hematological toxicity.
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In Vitro——
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In VivoMethotrexate (Amethopterin) disodium reduces thymus and spleen indices of mice. Methotrexate disodium markedly decreases white blood cells, thymic and splenic lymphocytes at dose ≥5 mg/kg. However, there is a significant difference between the treatment plus control group and the model group (p<0.01). The combination of grape seed proanthocyanidins and Siberian ginseng eleutherosides obviously diminishes the effects of Methotrexate exposure on indices of thymus and spleens in mice.Methotrexate (MTX) disodium (2 mg/kg; i.p.; once in a week for 5 weeks) is effective in Freund's complete adjuvant-induced arthritis. The combination of Methotrexate disodium (1 mg/kg; i.p.; once in a week for 5 weeks) and Curcumin (30 mg/kg and 100 mg/kg, thrice a week for 5 weeks; i.p.) shows a significant anti-arthritic action and protection from hematological toxicity.
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Synonyms——
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PathwayMetabolic Enzyme/Protease
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TargetDehydrogenase
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RecptorhDHFR(dihydrofolate reductase)
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Research AreaInflammation/Immunology
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IndicationRheumatoid Arthritis
Chemical Information
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CAS Number7413-34-5
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Formula Weight498.4
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Molecular FormulaC20H20N8Na2O5
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Purity>98% (HPLC)
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SolubilityH2O:99 mg/mL (198.63 mM)
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SMILESCN(Cc1cnc2nc(N)nc(N)c2n1)c1ccc(C(=O)NC(CCC(=O)[O-])C(=O)[O-])cc1.[Na+].[Na+]
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Chemical Name——
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1.Yang W Xia Y Fang Y et al. Selective Cell Penetrating Peptide-Functionalized Polymersomes Mediate Efficient and Targeted Delivery of Methotrexate Disodium to Human Lung Cancer In Vivo[J]. Advanced Healthcare Materials 2017:1701135.
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