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AUDA
CAS No. 479413-70-2
AUDA( —— )
Catalog No. M21149 CAS No. 479413-70-2
AUDA is an inhibitor of sEH(IC50 values of 18 and 69 nM for the mouse and human enzymes respectively).
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 1 mL x 10 mM in DMSO | 46 | In Stock |
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| 10MG | 42 | In Stock |
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| 25MG | 76 | In Stock |
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| 50MG | 120 | In Stock |
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| 100MG | 193 | In Stock |
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| 200MG | 306 | In Stock |
|
| 500MG | Get Quote | In Stock |
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| 1G | Get Quote | In Stock |
|
Biological Information
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Product NameAUDA
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NoteResearch use only, not for human use.
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Brief DescriptionAUDA is an inhibitor of sEH(IC50 values of 18 and 69 nM for the mouse and human enzymes respectively).
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DescriptionAUDA is an inhibitor of sEH(IC50 values of 18 and 69 nM for the mouse and human enzymes respectively).
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In VitroAUDA (0.3-10 μg/mL; 48 hours) dose-dependently suppresses the proliferation of rat VSMCs exposed to PDGF. AUDA (0.3-10 μg/mL; 30 min) dose-dependently upregulats COX-2 expression. AUDA (10, 50 and 100 μM) augments the migratory ability of HCAECs in a dose-dependent manner. AUDA significantly increases the adhesion ability of HCAECs. Cell Proliferation AssayCell Line:Vascular smooth muscle cell (VSMC)Concentration:0.3, 1, 3, 10 μg/mLIncubation Time:48 hoursResult:Dose-dependently suppressed the proliferation of rat VSMCs exposed to PDGF. Western Blot AnalysisCell Line:VSMC Concentration:1, 3, 10, 30 μg/mL Incubation Time:30 minResult:Dose-dependently upregulated COX-2 expression.
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In VivoAUDA (i.p.; 10 mg/kg; 14 days) reduces TNF-α, MMP-9 and IL-1β expression levels. Animal Model:Male (wild-type) C57BL/6 mice (age, 4-6 weeks; weight, 18-20 g) Dosage:10 mg/kg Administration:i.p.; 14 days Result:Reduced TNF-α, MMP-9 and IL-1β expression levels.
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Synonyms——
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PathwayOthers
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TargetOther Targets
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RecptorsEH
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Research Area——
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Indication——
Chemical Information
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CAS Number479413-70-2
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Formula Weight392.6
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Molecular FormulaC23H40N2O3
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Purity>98% (HPLC)
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SolubilityDMSO:1mg/ml(2.55mM)
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SMILESO=C(O)CCCCCCCCCCCNC(=O)NC12CC3CC(CC(C3)C1)C2
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Chemical Name12-[(Adamantan-1-ylcarbamoyl)amino]dodecanoic acid
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
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Alisol B 23-acetate
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Calcitonin, rat
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