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Nitecapone

CAS No. 116313-94-1

Nitecapone( —— )

Catalog No. M21089 CAS No. 116313-94-1

Nitecapone is a reversible inhibitor of S-COMT (IC50 values of 300 nM in rat liver).

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
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Biological Information

  • Product Name
    Nitecapone
  • Note
    Research use only, not for human use.
  • Brief Description
    Nitecapone is a reversible inhibitor of S-COMT (IC50 values of 300 nM in rat liver).
  • Description
    Nitecapone is a reversible inhibitor of S-COMT (IC50 values of 300 nM in rat liver).
  • In Vitro
    Nitecapone (1-100 μM) reducesd GSH (reduced glutathione) depletion induced by ROO-by 11-38% and oxidation to oxidized glutathione (GSSG) by 32-45%.
  • In Vivo
    Nitecapone (30 mg/kg, ip daily for 13 days) reduces development and symptoms of neuropathic pain after spinal nerve ligation in rats. Animal Model:Eighty-six male Wistar rats, weighing 140-350 g.Dosage:30 mg/kg (3.3 mL/kg).Administration:IP, once daily for 13 days.Result:Selectively and specifically inhibits COMT in the peripheral tissues, and to some extent in the CNS for ca. 3 h.Increased the thresholds for the mechanical stimuli and thus reduced mechanical allodynia.Reduced the number of positive reactions of the ipsilateral paws when compared with the baselines in the nitecapone-pretreated rats.
  • Synonyms
    ——
  • Pathway
    Others
  • Target
    Other Targets
  • Recptor
    S-COMT
  • Research Area
    ——
  • Indication
    ——

Chemical Information

  • CAS Number
    116313-94-1
  • Formula Weight
    265.22
  • Molecular Formula
    C12H11NO6
  • Purity
    >98% (HPLC)
  • Solubility
    In Vitro:?DMSO : 50 mg/mL (188.52 mM)
  • SMILES
    CC(=O)C(=Cc1cc(O)c(O)c([N+](=O)[O-])c1)C(C)=O
  • Chemical Name
    3-(34-Dihydroxy-5-nitrobenzylidene)-24-pentanedione

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1.P.T. M?nnist? Kaakkola S . Catechol-O-methyltransferase (COMT): Biochemistry molecular biology pharmacology and clinical efficacy of the new selective COMT inhibitors[J]. Pharmacological Reviews 2000 51(4):593-628.
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