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Lixivaptan

CAS No. 168079-32-1

Lixivaptan( VPA-985 | WAY-VPA 985 )

Catalog No. M20804 CAS No. 168079-32-1

Lixivaptan is an orally active and selective vasopressin receptor V2 antagonist(Ki = 2.3 nM).

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
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Biological Information

  • Product Name
    Lixivaptan
  • Note
    Research use only, not for human use.
  • Brief Description
    Lixivaptan is an orally active and selective vasopressin receptor V2 antagonist(Ki = 2.3 nM).
  • Description
    Lixivaptan is an orally active and selective vasopressin receptor V2 antagonist(Ki = 2.3 nM).
  • In Vitro
    ——
  • In Vivo
    ——
  • Synonyms
    VPA-985 | WAY-VPA 985
  • Pathway
    GPCR/G Protein
  • Target
    Vasopressin Receptor
  • Recptor
    Vasopressin Receptor
  • Research Area
    Metabolic Disease
  • Indication
    Autosomal dominant polycystic kidney disease

Chemical Information

  • CAS Number
    168079-32-1
  • Formula Weight
    473.93
  • Molecular Formula
    C27H21ClFN3O2
  • Purity
    >98% (HPLC)
  • Solubility
    DMSO:150 mg/mL (316.50 mM)
  • SMILES
    Cc1ccc(F)cc1C(=O)Nc1ccc(C(=O)N2Cc3cccn3Cc3ccccc32)c(Cl)c1
  • Chemical Name
    N-(3-chloro-4-(1011-dihydro-6H-benzo[e]pyrrolo[12-a][14]diazepine-5-carbonyl)phenyl)-5-fluoro-2-methylbenzamide

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1.Wang X Constans MM Chebib FT.et al.Effect of a Vasopressin V2 Receptor Antagonist on Polycystic Kidney Disease Development in a Rat Model[J].Am J Nephrol. 2019;49(6):487-493.
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