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Imeglimin hydrochloride
CAS No. 775351-61-6
Imeglimin hydrochloride( EMD 387008 hydrochloride )
Catalog No. M20797 CAS No. 775351-61-6
Imeglimin hydrochloride prevents human endothelial cell death by inhibiting mitochondrial permeability transition without inhibiting mitochondrial respiration.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 1 mL x 10 mM in DMSO | 206 | In Stock |
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| 2MG | 46 | In Stock |
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| 5MG | 75 | In Stock |
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| 10MG | 120 | In Stock |
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| 25MG | 218 | In Stock |
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| 50MG | 356 | In Stock |
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| 100MG | 538 | In Stock |
|
| 200MG | 755 | In Stock |
|
| 500MG | Get Quote | In Stock |
|
| 1G | Get Quote | In Stock |
|
Biological Information
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Product NameImeglimin hydrochloride
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NoteResearch use only, not for human use.
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Brief DescriptionImeglimin hydrochloride prevents human endothelial cell death by inhibiting mitochondrial permeability transition without inhibiting mitochondrial respiration.
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DescriptionImeglimin hydrochloride prevents human endothelial cell death by inhibiting mitochondrial permeability transition without inhibiting mitochondrial respiration.(In Vitro):Preincubation with Imeglimin (10 mM for 4 h or 100 μM for 24 h) also fully prevented tert-butylhydroperoxide (tBH)-induced cell death.(In Vivo):Imeglimin (200 mg/kg b.i.d. by oral gavage during the last 6 weeks of HFHSD feeding) significantly decreases hyperglycemia, and restores normal glucose tolerance.
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In VitroPreincubation with Imeglimin (10?mM for 4?h or 100?μM for 24?h) also fully prevented tert-butylhydroperoxide (tBH)-induced cell death. Cell Viability Assay Cell Line:Human endothelial cells (HMEC-1)Concentration:100?μM and10?mM Incubation Time:100?μM for 24?h, 10?mM for 4?h Result:Prevention of cell death.
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In VivoImeglimin (200 mg/kg b.i.d. by oral gavage during the last 6 weeks of HFHSD feeding) significantly decreases hyperglycemia, and restores normal glucose tolerance. Animal Model:Male C57BL/6JOlaHsd mice (4 weeks old)Dosage:200 mg/kg Administration:Oral gavage; b.i.d.; 6 weeks Result:A slight decrease in body weight and food intake associated with some diarrhea was observed but only during the first few days of treatment.
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SynonymsEMD 387008 hydrochloride
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PathwayOthers
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TargetOther Targets
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Recptormitochondrial phospholipid
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Research AreaMetabolic Disease
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IndicationType 2 diabetes mellitus
Chemical Information
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CAS Number775351-61-6
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Formula Weight191.66
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Molecular FormulaC6H14ClN5
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Purity>98% (HPLC)
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SolubilityDMSO:25 mg/mL (130.44 mM)
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SMILESC[C@@H]1N=C(N)NC(N(C)C)=N1.Cl
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Chemical Name——
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1.Detaille D Vial G Borel A L et al. Imeglimin prevents human endothelial cell death by inhibiting mitochondrial permeability transition without inhibiting mitochondrial respiration[J]. Cell death discovery 2016 2:15072.
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