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Yoda 1

CAS No. 448947-81-7

Yoda 1( —— )

Catalog No. M20782 CAS No. 448947-81-7

Yoda1 is a Piezo1 ion channel agonist (EC50s = 17.1 and 26.6 μM for murine and human Piezo1-transfected HEK293T cells respectively).

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
Size Price / USD Stock Quantity
1 mL x 10 mM in DMSO 90 In Stock
2MG 52 In Stock
5MG 83 In Stock
10MG 111 In Stock
25MG 231 In Stock
50MG 437 In Stock
100MG 641 In Stock
200MG Get Quote In Stock
500MG 1358 In Stock
1G Get Quote In Stock
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Biological Information

  • Product Name
    Yoda 1
  • Note
    Research use only, not for human use.
  • Brief Description
    Yoda1 is a Piezo1 ion channel agonist (EC50s = 17.1 and 26.6 μM for murine and human Piezo1-transfected HEK293T cells respectively).
  • Description
    Yoda1 is a Piezo1 ion channel agonist (EC50s = 17.1 and 26.6 μM for murine and human Piezo1-transfected HEK293T cells respectively).
  • In Vitro
    Western Blot Analysis Cell Line:human coronary artery endothelial cells (HCAECs), A431 cellsConcentration:0, 1.5, 3.0, and 6.0?μM Incubation Time:5 min Result:Induced the activation of both Akt and ERK1/2, and increased the phosphorylation levels of both Akt and ERK1/2 in a dose-dependent manner. Inhibited EGF-induced increase in the amount of Rac1-GTP, and inhibited Rac1 activation
  • In Vivo
    ——
  • Synonyms
    ——
  • Pathway
    Others
  • Target
    Other Targets
  • Recptor
    Piezo1
  • Research Area
    ——
  • Indication
    ——

Chemical Information

  • CAS Number
    448947-81-7
  • Formula Weight
    355.27
  • Molecular Formula
    C13H8Cl2N4S2
  • Purity
    >98% (HPLC)
  • Solubility
    DMSO:34 mg/mL (95.70 mM)
  • SMILES
    Clc1cccc(Cl)c1CSc1nnc(-c2cnccn2)s1
  • Chemical Name
    2-[5-(26-Dichloro-benzylsulfanyl)-[134]thiadiazol-2-yl]-pyrazine

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1.Ruhma S Jie X Dubin A E et al. Chemical activation of the mechanotransduction channel Piezo1[J]. eLife 2015 4.
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