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BAY-598
CAS No. 1906919-67-2
BAY-598( —— )
Catalog No. M20776 CAS No. 1906919-67-2
BAY-598 is a selective inhibitor of SMYD2 with IC50 values of 27 nM.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 5MG | 96 | In Stock |
|
| 10MG | 152 | In Stock |
|
| 25MG | 237 | In Stock |
|
| 50MG | 401 | In Stock |
|
| 100MG | 647 | In Stock |
|
| 200MG | Get Quote | In Stock |
|
| 500MG | Get Quote | In Stock |
|
| 1G | Get Quote | In Stock |
|
Biological Information
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Product NameBAY-598
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NoteResearch use only, not for human use.
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Brief DescriptionBAY-598 is a selective inhibitor of SMYD2 with IC50 values of 27 nM.
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DescriptionBAY-598 is a selective inhibitor of SMYD2 with IC50 values of 27 nM.
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In VitroBAY-598 treatment blocks in vitro methylation of MAPKAPK3 by SMYD2 but has no activity against the SMYD2-related KMT SMYD3. BAY-598 treatment reduces the growth of Kras;p53 mutant PDAC cells after 9 d in culture but has little impact on the growth of Kras;p53;Smyd2 mutant cells.
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In Vivo——
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Synonyms——
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PathwayChromatin/Epigenetic
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TargetHistone Demethylase
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RecptorSMYD2
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Research Area——
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Indication——
Chemical Information
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CAS Number1906919-67-2
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Formula Weight525.34
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Molecular FormulaC22H20Cl2F2N6O3
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Purity>98% (HPLC)
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SolubilityDMSO:125 mg/mL (237.94 mM)
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SMILESCCN(C(=O)CO)C1CN(C(=Nc2cccc(OC(F)F)c2)NC#N)N=C1c1ccc(Cl)c(Cl)c1
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Chemical Name——
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1.Reynoird N Mazur P K Stellfeld T et al. Coordination of stress signals by the lysine methyltransferase SMYD2 promotes pancreatic cancer[J]. Genes & Development 2016:genesdev;gad.275529.115v1.
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