Cart
sales@molnova.com
Home - Products - Chromatin/Epigenetic - Histone Demethylase - SGC-iMLLT

SGC-iMLLT

CAS No. 2255338-25-9

SGC-iMLLT( —— )

Catalog No. M26437 CAS No. 2255338-25-9

SGC-iMLLT is a potent and selective MLLT1/3-histone interactions inhibitor(IC50 = 0.26 μM),and is a first-in-class chemical probe displaying cellular target engagement of MLLT1(Kd = 0.129 μM) and MLLT3(Kd = 0.077 μM).

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
Size Price / USD Stock Quantity
2MG 44 Get Quote
100MG Get Quote Get Quote
200MG Get Quote Get Quote
500MG Get Quote Get Quote
1G Get Quote Get Quote
Get Quotation Bulk Inquiry Add to Cart

Biological Information

  • Product Name
    SGC-iMLLT
  • Note
    Research use only, not for human use.
  • Brief Description
    SGC-iMLLT is a potent and selective MLLT1/3-histone interactions inhibitor(IC50 = 0.26 μM),and is a first-in-class chemical probe displaying cellular target engagement of MLLT1(Kd = 0.129 μM) and MLLT3(Kd = 0.077 μM).
  • Description
    SGC-iMLLT is a potent and selective MLLT1/3-histone interactions inhibitor(IC50 = 0.26 μM),and is a first-in-class chemical probe displaying cellular target engagement of MLLT1(Kd = 0.129 μM) and MLLT3(Kd = 0.077 μM).(In Vivo):After 60 min, SGC-iMLLT shows moderate metabolic resistance (t1/2 53 min, 48 % remaining), with a primary process for metabolism being N demethylation.
  • In Vitro
    ——
  • In Vivo
    ——
  • Synonyms
    ——
  • Pathway
    Chromatin/Epigenetic
  • Target
    Histone Demethylase
  • Recptor
    Antibacterial
  • Research Area
    ——
  • Indication
    ——

Chemical Information

  • CAS Number
    2255338-25-9
  • Formula Weight
    388.475
  • Molecular Formula
    C22H24N6O
  • Purity
    >98% (HPLC)
  • Solubility
    In Vitro:?DMSO : 83.33 mg/mL (214.51 mM)
  • SMILES
    C[C@H]1CCCN1Cc1nc2cc(NC(=O)c3ccc4n(C)ncc4c3)ccc2[nH]1
  • Chemical Name
    ——

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1.Christoffersson E, Edlund Y, Gamklou R, Nilsson LA. Microbiological activity of sulfaproxyline-sulfamerazine in gallbladder bile from patients with gallstone disease. Scand J Clin Lab Invest. 1966;18(2):254-60.
Calculator

Molecular Weight Calculator

Dilution Calculator

Molarity Calculator

molnova catalog
related products

  • E67-2

    E67-2 is a potent and selective inhibitor of H3K9 Jumonji demethylase KIAA1718 (KDM7A) with IC50 of 3.4 uM.

  • M?89

    M-89 inhibits the menin-mixed lineage leukemia (Menin-MLL) protein-protein interaction and has potential to treat MLL leukemia.?M-89 is a highly potent and specific menin inhibitor, with a Kd of 1.4 nM for binding to menin.

  • QC-6352

    QC-6352 is a potent and selective KDM4 family inhibitor.

Sign In Join Free