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NECA

CAS No. 35920-39-9

NECA( 5'-N-Ethylcarboxamidoadenosine )

Catalog No. M20741 CAS No. 35920-39-9

NECA is an agonist of Adenosine receptor increases cerebral extravasation of fluorescein and low molecular weight dextran independent of blood-brain barrier modulation.

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
Size Price / USD Stock Quantity
1 mL x 10 mM in DMSO 54 In Stock
5MG 39 In Stock
10MG 48 In Stock
25MG 92 In Stock
50MG 136 In Stock
100MG 202 In Stock
200MG Get Quote In Stock
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Biological Information

  • Product Name
    NECA
  • Note
    Research use only, not for human use.
  • Brief Description
    NECA is an agonist of Adenosine receptor increases cerebral extravasation of fluorescein and low molecular weight dextran independent of blood-brain barrier modulation.
  • Description
    NECA is an agonist of Adenosine receptor increases cerebral extravasation of fluorescein and low molecular weight dextran independent of blood-brain barrier modulation.
  • In Vitro
    ——
  • In Vivo
    After the administration of 5'-N-Ethylcarboxamidoadenosine (NECA), the mean number of cocaine infusions obtained per session is decreased significantly in a dose-dependent manner [5'-N-Ethylcarboxamidoadenosine (NECA): F(4,12)=14.9; P<0.001]. The administration of 5'-N-Ethylcarboxamidoadenosine (NECA) [F(4,12)=16.1; P<0.001] results in a significant increase in latencies above values obtained for vehicle treatment. Daily i.p. injection of 5'-N-Ethylcarboxamidoadenosine (NECA) at 0.3 mg/kg/day for two weeks reduces malondialdehyde (MDA) levels in diabetic rats, but does not affect control rats. Daily treatment with NECA (0.3 mg/kg/day, i.p. for two weeks) reduces diabetes-induced gene expression of tumor necrosis factor (TNF)-α and interleukin (IL)-18 in diabetic rats, but does not affect control rats. Daily i.p. injection of 5'-N-Ethylcarboxamidoadenosine (NECA) at 0.3 mg/kg/day for two weeks also blocks the activation of JNK MAPK in diabetic rats, but does not affect control rats.
  • Synonyms
    5'-N-Ethylcarboxamidoadenosine
  • Pathway
    Endocrinology/Hormones
  • Target
    AChR
  • Recptor
    Adenosine receptor
  • Research Area
    ——
  • Indication
    ——

Chemical Information

  • CAS Number
    35920-39-9
  • Formula Weight
    308.29
  • Molecular Formula
    C12H16N6O4
  • Purity
    >98% (HPLC)
  • Solubility
    DMSO:150 mg/mL (486.55 mM)
  • SMILES
    CCNC(=O)[C@H]1O[C@H]([C@H](O)[C@@H]1O)n1cnc2c(N)ncnc12
  • Chemical Name
    ——

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1.Beckman B S Agrawal K C Fisher J W et al. Effects of 5′-N-ethylcarboxamideadenosine (NECA) on erythropoietin production[J]. Kidney International 1993 44(4):734-740.
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