Ralfinamide

Research use only, not for human use.

Ralfinamide is an orally available Na-channel blocker for the treatment of neuropathic pain and other pain conditions.

Ralfinamide is an orally available Na-channel blocker for the treatment of neuropathic pain and other pain conditions.(In Vivo):Ralfinamide (30 mg/kg, 60 mg/kg; p.o.; twice daily; 42 days) treated with Ralfinamide (80 mg/kg; p.o.; twice daily; 7 days) preoperatively suppresses neuropathic pain.

——

Ralfinamide (30 mg/kg, 60 mg/kg; p.o.; twice daily; 42 days) treated with Ralfinamide (80 mg/kg; p.o.; twice daily; 7 days) preoperatively suppresses neuropathic pain. Animal Model:81 adult male Sprague–Dawley male rats (260–460 g)Dosage:80 mg/kg (7 days preoperatively), 30 mg/kg, 60 mg/kg (postoperative)Administration:Oral gavage; twice daily; until postoperative day 42Result:Suppressed neuropathic pain.

FCE-26742A | Priralfinamide

Membrane Transporter/Ion Channel

Sodium Channel

Na-channel

Neurological Disease

Neuropathic pain

133865-88-0

302.34

C17H19FN2O2

>98% (HPLC)

DMSO:125 mg/mL (413.44 mM)

C[C@H](NCc1ccc(OCc2ccccc2F)cc1)C(N)=O

(2S)-2-(4-(2-Fluorobenzyloxy)benzylamino)propanamide

(-20℃)

With Ice Pack

≥ 2 years