Cart
sales@molnova.com
Rubitecan
CAS No. 91421-42-0
Rubitecan( RFS 2000 | 9-Nitrocamptothecin )
Catalog No. M20618 CAS No. 91421-42-0
Rubitecan is a DNA topoisomerase I inhibitor. It inhibits DNA topoisomerase I and increases the fraction of supercoiled DNA in a cell-free assay in a concentration-dependent manner.Rubitecan is a semisynthetic agent related to camptothecin with potent antitumor and antiviral properties.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 1 mL x 10 mM in DMSO | 29 | In Stock |
|
| 10MG | 38 | In Stock |
|
| 25MG | 85 | In Stock |
|
| 50MG | 120 | In Stock |
|
| 100MG | 179 | In Stock |
|
| 200MG | Get Quote | In Stock |
|
| 500MG | Get Quote | In Stock |
|
| 1G | Get Quote | In Stock |
|
Biological Information
-
Product NameRubitecan
-
NoteResearch use only, not for human use.
-
Brief DescriptionRubitecan is a DNA topoisomerase I inhibitor. It inhibits DNA topoisomerase I and increases the fraction of supercoiled DNA in a cell-free assay in a concentration-dependent manner.Rubitecan is a semisynthetic agent related to camptothecin with potent antitumor and antiviral properties.
-
DescriptionRubitecan is a DNA topoisomerase I inhibitor. It inhibits DNA topoisomerase I and increases the fraction of supercoiled DNA in a cell-free assay in a concentration-dependent manner.Rubitecan is a semisynthetic agent related to camptothecin with potent antitumor and antiviral properties.(In Vitro):Rubitecan (RFS 2000) inhibits U-CH1, U-CH2, and CCL4 cells with IC50s 0.32, 0.83, and 7.7 μM, respectively.
-
In VitroRubitecan (RFS 2000) inhibits U-CH1, U-CH2, and CCL4 cells with IC50s 0.32, 0.83, and 7.7 μM, respectively.
-
In Vivo——
-
SynonymsRFS 2000 | 9-Nitrocamptothecin
-
PathwayCell Cycle/DNA Damage
-
TargetTopoisomerase
-
Recptortopoisomerase I
-
Research AreaCancer
-
IndicationTumors
Chemical Information
-
CAS Number91421-42-0
-
Formula Weight393.35
-
Molecular FormulaC20H15N3O6
-
Purity>98% (HPLC)
-
SolubilityDMSO:125 mg/mL (317.78 mM)
-
SMILESCC[C@@]1(O)C(=O)OCc2c1cc1-c3nc4cccc([N+]([O-])=O)c4cc3Cn1c2=O
-
Chemical Name(S)-4-ethyl-4-hydroxy-10-nitro-1H-pyrano[3'4':67]indolizino[12-b]quinoline-314(4H12H)-dione
Shipping & Storage Information
-
Storage(-20℃)
-
ShippingWith Ice Pack
-
Stability≥ 2 years
Reference
1.Sands H Mishra A Stoeckler J D et al. Preclinical activity of an i.v. formulation of rubitecan in IDD-P? against human solid tumor xenografts[J]. Anti-Cancer Drugs 2002 13(9):965-975.
molnova catalog
related products
-
DRF-1042
DRF-1042, an orally active camptothecin analog, exhibits anticancer and insecticidal activities by inhibiting DNA topoisomerase I. It has been studied for its efficacy against solid tumors, including prostate and colon cancers.
-
SN-38
LE-SN38 is NeoPharm’s NeoLipid liposomal formulation of SN-38, the active metabolite of irinotecan (Camptosar), a chemotherapeutic pro-drug approved for the treatment of advanced colorectal Y.
-
UAMC 00039 dihydroch...
UAMC00039 dihydrochloride is a potent, reversible and competitive dipeptidyl peptidase II inhibitor with an IC50 of 0.48 nM.
