Cart
sales@molnova.com
Rubitecan
CAS No. 91421-42-0
Rubitecan( RFS 2000 | 9-Nitrocamptothecin )
Catalog No. M20618 CAS No. 91421-42-0
Rubitecan is a DNA topoisomerase I inhibitor. It inhibits DNA topoisomerase I and increases the fraction of supercoiled DNA in a cell-free assay in a concentration-dependent manner.Rubitecan is a semisynthetic agent related to camptothecin with potent antitumor and antiviral properties.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 10MG | 63 | In Stock |
|
| 50MG | 151 | In Stock |
|
| 100MG | 227 | In Stock |
|
| 200MG | Get Quote | In Stock |
|
| 500MG | Get Quote | In Stock |
|
| 1G | Get Quote | In Stock |
|
Biological Information
-
Product NameRubitecan
-
NoteResearch use only, not for human use.
-
Brief DescriptionRubitecan is a DNA topoisomerase I inhibitor. It inhibits DNA topoisomerase I and increases the fraction of supercoiled DNA in a cell-free assay in a concentration-dependent manner.Rubitecan is a semisynthetic agent related to camptothecin with potent antitumor and antiviral properties.
-
DescriptionRubitecan is a DNA topoisomerase I inhibitor. It inhibits DNA topoisomerase I and increases the fraction of supercoiled DNA in a cell-free assay in a concentration-dependent manner.Rubitecan is a semisynthetic agent related to camptothecin with potent antitumor and antiviral properties.(In Vitro):Rubitecan (RFS 2000) inhibits U-CH1, U-CH2, and CCL4 cells with IC50s 0.32, 0.83, and 7.7 μM, respectively.
-
In VitroRubitecan (RFS 2000) inhibits U-CH1, U-CH2, and CCL4 cells with IC50s 0.32, 0.83, and 7.7 μM, respectively.
-
In Vivo——
-
SynonymsRFS 2000 | 9-Nitrocamptothecin
-
PathwayCell Cycle/DNA Damage
-
TargetTopoisomerase
-
Recptortopoisomerase I
-
Research AreaCancer
-
IndicationTumors
Chemical Information
-
CAS Number91421-42-0
-
Formula Weight393.35
-
Molecular FormulaC20H15N3O6
-
Purity>98% (HPLC)
-
SolubilityDMSO:125 mg/mL (317.78 mM)
-
SMILESCC[C@@]1(O)C(=O)OCc2c1cc1-c3nc4cccc([N+]([O-])=O)c4cc3Cn1c2=O
-
Chemical Name(S)-4-ethyl-4-hydroxy-10-nitro-1H-pyrano[3'4':67]indolizino[12-b]quinoline-314(4H12H)-dione
Shipping & Storage Information
-
Storage(-20℃)
-
ShippingWith Ice Pack
-
Stability≥ 2 years
Reference
1.Sands H Mishra A Stoeckler J D et al. Preclinical activity of an i.v. formulation of rubitecan in IDD-P? against human solid tumor xenografts[J]. Anti-Cancer Drugs 2002 13(9):965-975.
molnova catalog
related products
-
Lomefloxacin
Lomefloxacin is a fluoroquinolone antibiotic, used to treat bacterial infections including bronchitis and urinary tract infections.
-
Enoxacin
Enoxacin is a broad-spectrum 6-fluoronaphthyridinone antibacterial agent.
-
Lomefloxacin hydroch...
Lomefloxacin hydrochloride (Maxaquin) is a hydrochloride salt of lomefloxacin and is a fluoroquinolone antibiotic.
