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Alpha-Methyldopa Sesquihydrate
CAS No. 41372-08-1
Alpha-Methyldopa Sesquihydrate( MK-351 hydrate | Methyldopa hydrate | Methyldopa Sesquihydrate | L-(-)-α-Methyldopa hydrate )
Catalog No. M20585 CAS No. 41372-08-1
Alpha-Methyldopa Sesquihydrate is a DOPA decarboxylase inhibitor and indirect α2-adrenergic receptor agonist used to treat hypertension. It inhibits the sympathetic nervous system decreases production of dopamine norepinephrine and epinephrine and exhibits NO-dependent sedative activity.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 1 mL x 10 mM in DMSO | 28 | In Stock |
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| 100MG | Get Quote | In Stock |
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| 200MG | Get Quote | In Stock |
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| 500MG | 27 | In Stock |
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| 1G | Get Quote | In Stock |
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Biological Information
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Product NameAlpha-Methyldopa Sesquihydrate
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NoteResearch use only, not for human use.
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Brief DescriptionAlpha-Methyldopa Sesquihydrate is a DOPA decarboxylase inhibitor and indirect α2-adrenergic receptor agonist used to treat hypertension. It inhibits the sympathetic nervous system decreases production of dopamine norepinephrine and epinephrine and exhibits NO-dependent sedative activity.
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DescriptionAlpha-Methyldopa Sesquihydrate is a DOPA decarboxylase inhibitor and indirect α2-adrenergic receptor agonist used to treat hypertension. It inhibits the sympathetic nervous system decreases production of dopamine norepinephrine and epinephrine and exhibits NO-dependent sedative activity.(In Vivo):Methyldopa hydrate (L-(-)-α-Methyldopa hydrate; 200 mg/kg; i.p.) decreases the hyperglycemic response in the first 2 hr after Dieldrin treatment.
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In Vitro——
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In VivoMethyldopa hydrate (L-(-)-α-Methyldopa hydrate; 200 mg/kg; i.p.) decreases the hyperglycemic response in the first 2 hr after Dieldrin treatment. Animal Model:60-day-old male rats Dosage:200 mg/kg Administration: i.p.Result:Decreased the plasma concentration of glucose in Dieldrin-exposed rats by 24% during the 30 min following its administration.
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SynonymsMK-351 hydrate | Methyldopa hydrate | Methyldopa Sesquihydrate | L-(-)-α-Methyldopa hydrate
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PathwayGPCR/G Protein
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TargetDopamine Receptor
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RecptorDOPA decarboxylase
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Research Area——
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Indication——
Chemical Information
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CAS Number41372-08-1
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Formula Weight238.24
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Molecular FormulaC10H13NO4·3/2H?O
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Purity>98% (HPLC)
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SolubilityDMSO:33.33 mg/mL (139.90 mM)
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SMILESO.O.O.C[C@](N)(Cc1ccc(O)c(O)c1)C(O)=O.C[C@](N)(Cc1ccc(O)c(O)c1)C(O)=O
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Chemical Name(S)-2-amino-3-(34-dihydroxyphenyl)-2-methylpropanoic acid sesquihydrate
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1.Baila M R Cintas J A . [The use of the combination of L-alpha-methyldopa and dichlorothiazide in the treatment of arterial hypertension][J]. El Día Médico 1962 34:2422.
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