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ERK5-IN-1
CAS No. 1234479-76-5
ERK5-IN-1( —— )
Catalog No. M19955 CAS No. 1234479-76-5
ERK5-IN-1 is a potent ERK5 inhibitor (IC50: 87 nM). It also inhibits LRRK2[G2019S] (IC50: 26 nM).
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 1 mL x 10 mM in DMSO | 117 | In Stock |
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| 5MG | 116 | In Stock |
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| 10MG | 163 | In Stock |
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| 25MG | 243 | In Stock |
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| 50MG | 323 | In Stock |
|
| 100MG | 452 | In Stock |
|
| 200MG | Get Quote | In Stock |
|
| 500MG | Get Quote | In Stock |
|
| 1G | Get Quote | In Stock |
|
Biological Information
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Product NameERK5-IN-1
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NoteResearch use only, not for human use.
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Brief DescriptionERK5-IN-1 is a potent ERK5 inhibitor (IC50: 87 nM). It also inhibits LRRK2[G2019S] (IC50: 26 nM).
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DescriptionERK5-IN-1 is a potent ERK5 inhibitor (IC50: 87 nM). It also inhibits LRRK2[G2019S] (IC50: 26 nM).
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In VitroERK5-IN-1 (Compound 5) exhibits a cellular EC50 for inhibiting epidermal growth factor (EGF) induced ERK5 autophosphorylation of 0.19±0.04 μM.
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In Vivo——
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Synonyms——
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PathwayMAPK/ERK Signaling
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TargetERK
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RecptorERK5
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Research Area——
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Indication——
Chemical Information
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CAS Number1234479-76-5
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Formula Weight459.54
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Molecular FormulaC25H29N7O2
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Purity>98% (HPLC)
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SolubilityDMSO: 10 mM
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SMILESCOc1cc(ccc1Nc1ncc2N(C)C(=O)c3ccccc3N(C)c2n1)N1CCN(C)CC1
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Chemical Name6H-Pyrimido[45-b][14]benzodiazepin-6-one 511-dihydro-2-[[2-methoxy-4-(4-methyl-1-piperazinyl)phenyl]amino]-511-dimethyl-
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1.Deng X et al. Structural determinants for ERK5 (MAPK7) and leucine rich repeat kinase 2 activities of benzo[e]pyrimido-[54-b]diazepine-6(11H)-ones. Eur J Med Chem. 2013;70:758-767.
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