trans-Ferulic acid

Research use only, not for human use.

Trans-Ferulic acid causes the phosphorylation of β-catenin resulting in proteasomal degradation of β-catenin and increases the expression of pro-apoptotic factor Bax and decreases the expression of pro-survival factor survivin.trans-Ferulic acid exert both anti-proliferation and anti-migration effects in the human lung cancer cell line H1299.

Trans-Ferulic acid causes the phosphorylation of β-catenin resulting in proteasomal degradation of β-catenin and increases the expression of pro-apoptotic factor Bax and decreases the expression of pro-survival factor survivin.trans-Ferulic acid exert both anti-proliferation and anti-migration effects in the human lung cancer cell line H1299.

Cell Proliferation Assay Cell Line:H1299 Concentration:0.03-0.6 mM Incubation Time:24 h, 48 h Result:Low dose had no significant cytotoxic effect, but cytotoxicity was observed with 0.3 and 0.6 mM for 48 h.Apoptosis Analysis Cell Line:H1299 Concentration:0.03-0.6 mMIncubation Time: 48 h Result:Caused the arrest of the cell cycle at G0/G1 and a decrease in the percentage of the G2/M phase. And induced a significant increase in apoptotic populations. with 0.6 mM Cell Migration Assay Cell Line:H1299 Concentration:0.03-0.6 mM Incubation Time:16 h, (48 h)Result:Inhibited cell migration and invasion. by reducing the activity of MMP?2 and MMP?9 and increased β-catenin phosphorylation at Thr41/Ser45 but did not affect β-catenin protein levels.

Animal Model:Male Wister Albino Rat model Dosage: 100 mg/kg Administration:i.g, once a day for 21 daysResult:Decreased tamoxifen-induced elevated enzyme activities of AST, ALT, and ALP and ameliorated the decrease in the hepatic enzyme activities.

(E)-Coniferic acid

Angiogenesis

Bcl-2

Bax

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537-98-4

194.18

C10H10O4?

>98% (HPLC)

In Vitro:?DMSO : 100 mg/mL (514.99 mM)

COc1cc(\C=C\C(O)=O)ccc1O

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(-20℃)

With Ice Pack

≥ 2 years