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Home - Products - Angiogenesis - Bcl-2 - Sabutoclax

Sabutoclax

CAS No. 1228108-65-3

Sabutoclax( BI-97C1 )

Catalog No. M10887 CAS No. 1228108-65-3

Sabutoclax (BI-97C1) is a potent, pan Bcl-2 family proteins inhibitor.

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
Size Price / USD Stock Quantity
1 mL x 10 mM in DMSO 161 In Stock
5MG 147 In Stock
10MG 235 In Stock
25MG 472 In Stock
50MG 733 In Stock
100MG 995 In Stock
200MG Get Quote In Stock
500MG Get Quote In Stock
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Biological Information

  • Product Name
    Sabutoclax
  • Note
    Research use only, not for human use.
  • Brief Description
    Sabutoclax (BI-97C1) is a potent, pan Bcl-2 family proteins inhibitor.
  • Description
    Sabutoclax (BI-97C1) is a potent, pan Bcl-2 family proteins inhibitor that inhibits the binding of BH3 peptides to Bcl-XL, Bcl-2, Mcl-1 and Bfl-1 with IC50 of 0.31, 0.32, 0.20 and 0.62 uM; potently inhibits cell growth of human prostate cancer, lung cancer, and lymphoma cell lines withEC50 of 0.13, 0.56, and 0.049 uM, respectively; displays superior single-agent antitumor efficacy in prostate cancer mouse xenograft model.
  • In Vitro
    ——
  • In Vivo
    Animal Model:athymic nude mice with tumor xenografts from M2182 cells in s.c.Dosage:1 mg/kg, 3 mg/kg, 5 mg/kg Administration:Intraperitoneal injection (i.p.)Result:Showed ihibiting tumor growth to about 60% of the tumor volume.
  • Synonyms
    BI-97C1
  • Pathway
    Angiogenesis
  • Target
    Bcl-2
  • Recptor
    Mcl-1 , Bcl-xL , Bcl-2 , Bfl-1
  • Research Area
    Cancer
  • Indication
    ——

Chemical Information

  • CAS Number
    1228108-65-3
  • Formula Weight
    700.788
  • Molecular Formula
    C42H40N2O8
  • Purity
    >98% (HPLC)
  • Solubility
    Methanol : 75 mg/mL 107.02 mM
  • SMILES
    O=C(C1=C(O)C(O)=CC2=C(O)C(C3=C(C)C=C4C(C(NC[C@@H](C5=CC=CC=C5)C)=O)=C(O)C(O)=CC4=C3O)=C(C)C=C12)NC[C@@H](C6=CC=CC=C6)C
  • Chemical Name
    [2,2'-Binaphthalene]-5,5'-dicarboxamide, 1,1',6,6',7,7'-hexahydroxy-3,3'-dimethyl-N5,N5'-bis[(2R)-2-phenylpropyl]-,(1R)-

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1. Wei J, et al. J Med Chem. 2010 May 27;53(10):4166-76. 2. Dash R, et al. Proc Natl Acad Sci U S A. 2011 May 24;108(21):8785-90. 3. Azab B, et al. J Cell Physiol. 2012 May;227(5):2145-53. 4. Goff DJ, et al. Cell Stem Cell. 2013 Mar 7;12(3):316-28.
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