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CGP60474
CAS No. 164658-13-3
CGP60474( CGP-60474 | CGP 60474 )
Catalog No. M12513 CAS No. 164658-13-3
A potent CDK1 inhibitor with IC50 of 17 nM; exhibits lower potency at CDK2 and moderate potency at CDK4.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 1 mL x 10 mM in DMSO | 71 | In Stock |
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| 2MG | 38 | In Stock |
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| 5MG | 65 | In Stock |
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| 10MG | 93 | In Stock |
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| 25MG | 187 | In Stock |
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| 50MG | 325 | In Stock |
|
| 100MG | 536 | In Stock |
|
| 200MG | Get Quote | In Stock |
|
| 500MG | Get Quote | In Stock |
|
| 1G | Get Quote | In Stock |
|
Biological Information
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Product NameCGP60474
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NoteResearch use only, not for human use.
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Brief DescriptionA potent CDK1 inhibitor with IC50 of 17 nM; exhibits lower potency at CDK2 and moderate potency at CDK4.
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DescriptionA potent CDK1 inhibitor with IC50 of 17 nM; exhibits lower potency at CDK2 (IC50=50-80nM) and moderate potency at CDK4 (IC50=700 nM).
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In VitroCGP60474 (Compound A) is a potent VEGFR-2 inhibitor, with an IC50 of 84 nM. CGP60474 is also a PKC inhibitor, with competitive kinetics relative to ATP.
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In Vivo——
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SynonymsCGP-60474 | CGP 60474
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PathwayAngiogenesis
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TargetPKC
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RecptorPKC
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Research AreaCancer
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Indication——
Chemical Information
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CAS Number164658-13-3
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Formula Weight355.8214
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Molecular FormulaC18H18ClN5O
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Purity>98% (HPLC)
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Solubility10 mM in DMSO
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SMILESOCCCNC1=NC=CC(C2=NC(NC3=CC=CC(Cl)=C3)=NC=C2)=C1
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Chemical Name1-Propanol, 3-[[4-[2-[(3-chlorophenyl)amino]-4-pyrimidinyl]-2-pyridinyl]amino]-
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1. Ruetz S, et al. Curr Med Chem Anticancer Agents. 2003 Jan;3(1):1-14.
2. Kuo GH, et al. J Med Chem. 2005 Jul 14;48(14):4535-46.
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