Guggulsterone E&Z( —— )

Catalog No. M20304 CAS No. 95975-55-6

COA

Datasheet

HNMR

HPLC

MSDS

Handing Instructions

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Product Name

Guggulsterone E&Z
Note

Research use only, not for human use.
Brief Description

Guggulsterone E&Z is a 3-hydroxy steroid. It has a role as an androgen.
Description

Guggulsterone E&Z is a 3-hydroxy steroid. It has a role as an androgen.
In Vitro

Western Blot Analysis Cell Line:RAW 264.7 murine macrophage cells Concentration:0.5, 5, 10, 20 μM Incubation Time:24 hours Result:Suppressed TREM-1, TLR4, and TNF-α expression as well as the phosphorylation of IκBα and NF-κB p65 by LPS.
In Vivo

Animal Model:Wild-type mice with TNBS-induced colitis Dosage:100 mg/kg Administration:Orally; once per day; for 8 days Result:Improved the survival rates of wild-type mice with TNBS-induced colitis.
Synonyms

——
Pathway

Cytoskeleton/Cell Adhesion Molecules
Target

Akt
Recptor

JNK|Akt|Caspase
Research Area

——
Indication

——

CAS Number

95975-55-6
Formula Weight

312.4
Molecular Formula

C21H28O2?
Purity

>98% (HPLC)
Solubility

DMSO:20.83 mg/mL?(66.67 mM）
SMILES

[H][C@@]12CC(=O)C(=CC)[C@@]1(C)CC[C@@]1([H])[C@@]2([H])CCC2=CC(=O)CC[C@]12C
Chemical Name

(8R9S10R13S14SZ)-17-ethylidene-1013-dimethyl-1678910111213141517-dodecahydro-3H-cyclopenta[a]phenanthrene-316(2H)-dione

1.Jackson D A Rosenzweig J A Azu N et al. Guggulsterone for Chemoprevention of Cancer[J]. Current Pharmaceutical Design 2016 22(3):-.

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