Cart
sales@molnova.com
A-674563 hydrochloride
CAS No. ——
A-674563 hydrochloride( A 674563 hydrochloride | A674563 hydrochloride )
Catalog No. M17012 CAS No. ——
A-674563 is a potent, selective and orally available AKT inhibitor with Ki of 11 nM (Akt1).
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 100MG | Get Quote | Get Quote |
|
| 200MG | Get Quote | Get Quote |
|
| 500MG | Get Quote | Get Quote |
|
| 1G | Get Quote | Get Quote |
|
Biological Information
-
Product NameA-674563 hydrochloride
-
NoteResearch use only, not for human use.
-
Brief DescriptionA-674563 is a potent, selective and orally available AKT inhibitor with Ki of 11 nM (Akt1).
-
DescriptionA-674563 is a potent, selective and orally available AKT inhibitor with Ki of 11 nM (Akt1); increases the efficacy of paclitaxel in a PC-3 xenograft model; enhances the transcription of several chondrocyte marker genes, including Col2a1, Acan and Col11a2, in mouse primary chondrocytes by inhibiting Sox9 degradation through the ubiquitin-proteasome pathway; also suppresses FLT3-ITD positive AML both in vitro and in vivo.
-
In Vitro——
-
In Vivo——
-
SynonymsA 674563 hydrochloride | A674563 hydrochloride
-
PathwayCytoskeleton/Cell Adhesion Molecules
-
TargetAkt
-
RecptorAkt
-
Research Area——
-
Indication——
Chemical Information
-
CAS Number——
-
Formula Weight——
-
Molecular FormulaC22H23ClN4O
-
Purity>98% (HPLC)
-
SolubilityDMSO: ≥ 30 mg/mL
-
SMILES——
-
Chemical Name(S)-1-((5-(3-methyl-1H-indazol-5-yl)pyridin-3-yl)oxy)-3-phenylpropan-2-amine hydrochloride
Shipping & Storage Information
-
Storage(-20℃)
-
ShippingWith Ice Pack
-
Stability≥ 2 years
Reference
1. Luo Y, et al. Mol Cancer Ther. 2005 Jun;4(6):977-86.
2. Tei H, et al. Hum Cell. 2015 Jul;28(3):114-21.
3. Wang A, et al. Oncotarget. 2016 May 17;7(20):29131-42.
4. Kobayashi T, et al. Biochem Biophys Res Commun. 2018 Jan 1;495(1):1468-1475.
molnova catalog
related products
-
CCT128930
CCT128930 is a potent, selective, ATP-competitive AKT inhibitor with IC50 of 6 nM (AKT2).
-
B-Raf inhibitor 1 di...
B-Raf inhibitor 1 is a potent and selective B-Raf inhibitor.
-
Iso-H7 dihydrochlori...
Iso-H7 dihydrochloride is a less potent inhibitor of phosphokinase C than H-7.
