Cart
sales@molnova.com
Apigenin-7-glucuronide
CAS No. 29741-09-1
Apigenin-7-glucuronide( Apigenin 7-O-glucuronide )
Catalog No. M20261 CAS No. 29741-09-1
Apigenin-7-glucuronide possesses multiple activities including antioxidant anti-inflammatory and aldose reductase inhibitory activities it can inhibit MMP activities (IC50s: 12.87 22.39 17.52 0.27 μM for MMP-3 MMP-8 MMP-9 MMP-13 respectively).
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 1 mL x 10 mM in DMSO | 103 | In Stock |
|
| 5MG | 93 | In Stock |
|
| 10MG | 148 | In Stock |
|
| 25MG | 249 | In Stock |
|
| 50MG | 362 | In Stock |
|
| 100MG | 532 | In Stock |
|
| 200MG | 793 | In Stock |
|
| 500MG | Get Quote | In Stock |
|
| 1G | Get Quote | In Stock |
|
Biological Information
-
Product NameApigenin-7-glucuronide
-
NoteResearch use only, not for human use.
-
Brief DescriptionApigenin-7-glucuronide possesses multiple activities including antioxidant anti-inflammatory and aldose reductase inhibitory activities it can inhibit MMP activities (IC50s: 12.87 22.39 17.52 0.27 μM for MMP-3 MMP-8 MMP-9 MMP-13 respectively).
-
DescriptionApigenin-7-glucuronide possesses multiple activities including antioxidant anti-inflammatory and aldose reductase inhibitory activities it can inhibit MMP activities (IC50s: 12.87 22.39 17.52 0.27 μM for MMP-3 MMP-8 MMP-9 MMP-13 respectively).(In Vitro):Apigenin-7-Oglucuronide could inhibit Matrix Metalloproteinases (MMP) activities, with IC50s of 12.87, 22.39, 17.52, 0.27 μM for MMP-3, MMP-8, MMP-9, MMP-13, respectively . Scutellarin A also inhibits the migrated capacity of ACHN and 786-O cells in a dose-dependent manner. It is also revealed that after treatment with Scutellarin A (30, 60, and 90 μM) for 24 h, the apoptosis rates in ACHN and 786-O cells are remarkably enhanced dose-dependently when compared to the control groups.
-
In VitroApigenin-7-Oglucuronide could inhibit Matrix Metalloproteinases (MMP) activities, with IC50s of 12.87, 22.39, 17.52, 0.27 μM for MMP-3, MMP-8, MMP-9, MMP-13, respectively . Scutellarin A also inhibits the migrated capacity of ACHN and 786-O cells in a dose-dependent manner. It is also revealed that after treatment with Scutellarin A (30, 60, and 90 μM) for 24 h, the apoptosis rates in ACHN and 786-O cells are remarkably enhanced dose-dependently when compared to the control groups.
-
In Vivo——
-
SynonymsApigenin 7-O-glucuronide
-
PathwayMetabolic Enzyme/Protease
-
TargetMMP
-
RecptorMMP-3| MMP-8|MMP-13| MMP-9
-
Research Area——
-
Indication——
Chemical Information
-
CAS Number29741-09-1
-
Formula Weight446.36
-
Molecular FormulaC21H18O11
-
Purity>98% (HPLC)
-
SolubilityDMSO: 50 mg/mL (112.02 mM)
-
SMILESO[C@H]1[C@H](Oc2cc(O)c3c(c2)oc(cc3=O)-c2ccc(O)cc2)O[C@@H]([C@@H](O)[C@@H]1O)C(O)=O
-
Chemical Name——
Shipping & Storage Information
-
Storage(-20℃)
-
ShippingWith Ice Pack
-
Stability≥ 2 years
Reference
1.Crascì L et al. Correlating In Vitro Target-Oriented Screening and Docking: Inhibition of Matrix Metalloproteinases Activities by Flavonoids. Planta Med. 2017 Jul;83(11):901-911.
molnova catalog
related products
-
NNGH
NNGH is a matrix metalloproteinase 3 (MMP-3) inhibitor with anticancer activity that counteracts the inhibitory effects of E2 and DHT on RANKL membrane binding.
-
Cipemastat
Cipemastat (Ro 32-3555) is a potent, second-generation, orally active MMP inhibitor.
-
Calycosin-7-O-beta-D...
Calycosin 7-O-β-D-glucoside has antimicrobial activity. Calycosin 7-O-β-D-glucoside is anticipated to be a promising anti-HIV agent.
