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Tyrosine kinase-IN-1

CAS No. 705946-27-6

Tyrosine kinase-IN-1( —— )

Catalog No. M20206 CAS No. 705946-27-6

Tyrosine kinase-IN-1 is a multi-targeted tyrosine kinase inhibitor(KDR Flt-1 FGFR1 and PDGFRα with IC50s of 4nM 20nM 4nM 2 nM respectively).

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
Size Price / USD Stock Quantity
1 mL x 10 mM in DMSO 59 In Stock
2MG 35 In Stock
5MG 53 In Stock
10MG 93 In Stock
25MG 187 In Stock
50MG 276 In Stock
100MG 398 In Stock
200MG Get Quote In Stock
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Biological Information

  • Product Name
    Tyrosine kinase-IN-1
  • Note
    Research use only, not for human use.
  • Brief Description
    Tyrosine kinase-IN-1 is a multi-targeted tyrosine kinase inhibitor(KDR Flt-1 FGFR1 and PDGFRα with IC50s of 4nM 20nM 4nM 2 nM respectively).
  • Description
    Tyrosine kinase-IN-1 is a multi-targeted tyrosine kinase inhibitor（KDR Flt-1 FGFR1 and PDGFRα with IC50s of 4nM 20nM 4nM 2 nM respectively）.
  • In Vitro
    Tyrosine kinase-IN-1 is from reference (compound 8K).
  • In Vivo
    Tyrosine kinase-IN-1 shows a reasonable PK profile (AUC(0–∞)=1.9, t1/2=4.6 h). It has a favorable oral bioavailability (F=63%) in rats.
  • Synonyms
    ——
  • Pathway
    Angiogenesis
  • Target
    VEGFR
  • Recptor
    KDR|Flt-1|FGFR1|PDGFRα|PDGFRα
  • Research Area
    ——
  • Indication
    ——

Chemical Information

  • CAS Number
    705946-27-6
  • Formula Weight
    445.54
  • Molecular Formula
    C26H28FN5O
  • Purity
    >98% (HPLC)
  • Solubility
    DMSO:62.5 mg/mL (160.47 mM)
  • SMILES
    CCN1CCC(CC1)Nc1ccc2NC(=O)\C(=C(/c3ncc(C)[nH]3)c3cccc(F)c3)c2c1
  • Chemical Name
    (Z)-5-((1-ethylpiperidin-4-yl)amino)-3-((3-fluorophenyl)(5-methyl-1H-imidazol-2-yl)methylene)indolin-2-one

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1.Moon K et al. The design synthesis and biological evaluation of potent receptor tyrosine kinase inhibitors. Bioorganic & Medicinal Chemistry Letters 22 (2012) 4979–4985
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