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HS-10296
CAS No. 1899921-05-1
HS-10296( —— )
Catalog No. M20205 CAS No. 1899921-05-1
Hs-10296 is an inhibitor of EGFR activation mutation and tolerant mutation of EGFR T790M which has only limited activity against wild-type EGFR.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 1 mL x 10 mM in DMSO | 249 | In Stock |
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| 5MG | 197 | In Stock |
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| 10MG | 312 | In Stock |
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| 25MG | 525 | In Stock |
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| 50MG | 740 | In Stock |
|
| 100MG | 1014 | In Stock |
|
| 200MG | Get Quote | In Stock |
|
| 500MG | 2065 | In Stock |
|
| 1G | Get Quote | In Stock |
|
Biological Information
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Product NameHS-10296
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NoteResearch use only, not for human use.
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Brief DescriptionHs-10296 is an inhibitor of EGFR activation mutation and tolerant mutation of EGFR T790M which has only limited activity against wild-type EGFR.
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DescriptionHs-10296 is an inhibitor of EGFR activation mutation and tolerant mutation of EGFR T790M which has only limited activity against wild-type EGFR.
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In VitroHS-10296 is an orally available inhibitor of the epidermal growth factor receptor (EGFR) mutant form T790M, with potential antineoplastic activity, which canbe used to treat NSCLC. Additionaly, HS-10296 could also inhibit other EGFR sensitive mutations, including G719X, del19, L858R and L861Q.
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In Vivo——
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Synonyms——
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PathwayAngiogenesis
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TargetEGFR
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RecptorEGFR (E746_A750/T790M)
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Research Area——
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Indication——
Chemical Information
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CAS Number1899921-05-1
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Formula Weight525.66
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Molecular FormulaC30H35N7O2
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Purity>98% (HPLC)
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SolubilityDMSO:100 mg/mL (190.24 mM);Ethanol:6 mg/mL (11.41 mM);Water:Insoluble
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SMILESCOc1cc(N(C)CCN(C)C)c(NC(=O)C=C)cc1Nc1nccc(n1)-c1cn(C2CC2)c2ccccc12
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Chemical NameN-(5-((4-(1-cyclopropyl-1H-indol-3-yl)pyrimidin-2-yl)amino)-2-((2-(dimethylamino)ethyl)(methyl)amino)-4-methoxyphenyl)acrylamide
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
molnova catalog
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