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GeA-69
CAS No. 2143475-98-1
GeA-69( —— )
Catalog No. M20135 CAS No. 2143475-98-1
GeA-69 (GeA69) is a selective and allosteric PARP14 macrodomain 2 (MD2) inhibitor (Kd: 0.86 μM in ITC assays).
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 1 mL x 10 mM in DMSO | 35 | In Stock |
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| 5MG | 33 | In Stock |
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| 10MG | 55 | In Stock |
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| 25MG | 112 | In Stock |
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| 50MG | 193 | In Stock |
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| 100MG | 267 | In Stock |
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| 200MG | 389 | In Stock |
|
| 500MG | Get Quote | In Stock |
|
| 1G | Get Quote | In Stock |
|
Biological Information
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Product NameGeA-69
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NoteResearch use only, not for human use.
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Brief DescriptionGeA-69 (GeA69) is a selective and allosteric PARP14 macrodomain 2 (MD2) inhibitor (Kd: 0.86 μM in ITC assays).
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DescriptionGeA-69 (GeA69) is a selective and allosteric PARP14 macrodomain 2 (MD2) inhibitor (Kd: 0.86 μM in ITC assays).
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In VitroGeA-69 (compound 1) (50 μM and 250 μM; pre-damage for 1 h or 0.5, 1, 2.5 min) engages PARP14 MD2 in intact cells and prevents its localisation to sites of DNA damage in U-2 OS cells. GeA-69 (25 nM-250 μM; 72 h) exhibits moderate cytotoxicity among HeLa, U-2 OS and HEK293 cells and highly cell permeable with 2 % passing paracellular and 98 % transcellular over the membrane. Cell Cytotoxicity Assay Cell Line:HeLa, U-2 OS and HEK293 cells Concentration:25 nM-250 μM Incubation Time:72 hours Result:Resulted moderate cytotoxicity against normal cells with EC50_HeLa=58 μM, EC50_U-2 OS=52 μM, EC50_HEK293=54 μM.
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In Vivo——
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Synonyms——
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PathwayCell Cycle/DNA Damage
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TargetPARP
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RecptorPARP14
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Research Area——
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Indication——
Chemical Information
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CAS Number2143475-98-1
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Formula Weight300.36
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Molecular FormulaC20H16N2O
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Purity>98% (HPLC)
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SolubilityDMSO: 120 mg/mL (399.53 mM)
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SMILESCC(=O)Nc1ccccc1-c1cccc2c3ccccc3[nH]c12
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Chemical NameN-(2-(9H-carbazol-1-yl)phenyl)acetamide
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1.Schuller M et al. Discovery of a Selective Allosteric Inhibitor Targeting Macrodomain 2 of Polyadenosine-Diphosphate-Ribose Polymerase 14. ACS Chem Biol. 2017 Nov 17;12(11):2866-2874.
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