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Rimeporide hydrochloride
CAS No. 187870-95-7
Rimeporide hydrochloride( EMD-87580 hydrochloride )
Catalog No. M20087 CAS No. 187870-95-7
Rimeporide (EMD-87580) is a potent and selective Sodium hydrogen exchange 1 (NHE-1) inhibitor.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 5MG | 187 | In Stock |
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| 10MG | 252 | In Stock |
|
| 25MG | 415 | In Stock |
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| 50MG | 551 | In Stock |
|
| 100MG | 775 | In Stock |
|
| 200MG | 1042 | In Stock |
|
| 500MG | Get Quote | In Stock |
|
| 1G | Get Quote | In Stock |
|
Biological Information
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Product NameRimeporide hydrochloride
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NoteResearch use only, not for human use.
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Brief DescriptionRimeporide (EMD-87580) is a potent and selective Sodium hydrogen exchange 1 (NHE-1) inhibitor.
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DescriptionRimeporide (EMD-87580) is a potent and selective Sodium hydrogen exchange 1 (NHE-1) inhibitor.
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In VitroBlocking NHE-1 activity has been shown to decrease intracellular Na+ and Ca2+ overload and pH and Rimeporide (EMD-87580) represents a new therapeutic option for duchenne muscular dystrophy (DMD). Rimeporide (EMD-87580) is expected to act as a muscle-sparing agent and its mode of action means that it is mutation independent.
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In Vivo——
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SynonymsEMD-87580 hydrochloride
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PathwayMembrane Transporter/Ion Channel
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TargetSodium Channel
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RecptorNHE-1
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Research Area——
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Indication——
Chemical Information
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CAS Number187870-95-7
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Formula Weight369.84
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Molecular FormulaC11H16ClN3O5S2
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Purity>98% (HPLC)
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SolubilityDMSO: 18.5 mg/mL (50 mM)
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SMILESCl.Cc1cc(c(cc1C(=O)NC(N)=N)S(C)(=O)=O)S(C)(=O)=O
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Chemical Name——
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1.Stanbouly S et al. Sodium hydrogen exchange 1 (NHE-1) regulates connexin 43 expression in cardiomyocytes via reverse mode sodium calcium exchange and c-Jun NH2-terminal kinase-dependent pathways. J Pharmacol Exp Ther. 2008 Oct;327(1):105-13.
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