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V9302
CAS No. 1855871-76-9
V9302( V 9302 | V-9302 )
Catalog No. M20085 CAS No. 1855871-76-9
V-9302 (V9302) is a competitive antagonist of transmembrane glutamine flux that selectively and potently targets the amino acid transporter ASCT2 (IC50: 9.6 uM).
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 5MG | 69 | In Stock |
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| 10MG | 113 | In Stock |
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| 25MG | 211 | In Stock |
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| 50MG | 375 | In Stock |
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| 100MG | 447 | In Stock |
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| 200MG | Get Quote | In Stock |
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| 500MG | Get Quote | In Stock |
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| 1G | Get Quote | In Stock |
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Biological Information
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Product NameV9302
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NoteResearch use only, not for human use.
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Brief DescriptionV-9302 (V9302) is a competitive antagonist of transmembrane glutamine flux that selectively and potently targets the amino acid transporter ASCT2 (IC50: 9.6 uM).
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DescriptionV-9302 (V9302) is a competitive antagonist of transmembrane glutamine flux that selectively and potently targets the amino acid transporter ASCT2 (IC50: 9.6 uM).
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In VitroV-9302 inhibits ASCT2-mediated glutamine uptake in human cells in a concentration-dependent fashion and exhibits a 100-fold improvement in potency over gamma-L-glutamyl-p-nitroanilide.Pharmacological blockade of ASCT2 with V-9302 results in attenuated cancer cell growth and proliferation, increases cell death, and increases oxidative stress.
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In VivoV-9302 (75 mg/kg; i.p.; daily fo 21 days) prevents tumor growth in both HCT-116 and HT29 xenograft models.The combination ofCB-839 and V-9302 (30 mg/kg; i.p.; SNU398 and MHCC97H cells were grown as tumor xenografts in BALB/c nude mice; for 20 or 15 d, respectively) elicits a strong growth inhibition in both SNU398 and MHCC97H xenograft models, while single-drug treatment showed modest anti-tumor effects.V-9302 (50 mg/kg ; i.p.; daily for 5 days) displays markedly reduced tumor growth. Animal Model:6-week old, female athymic nude mice (bearing HCT-116 (KRAS G13D) or HT29 (BRAF V600E) cell-line)Dosage:75 mg/kg Administration:Intraperitoneally; daily fo 21 daysResult:Prevented tumor growth.
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SynonymsV 9302 | V-9302
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PathwayOthers
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TargetOther Targets
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RecptorASCT2
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Research Area——
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Indication——
Chemical Information
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CAS Number1855871-76-9
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Formula Weight538.69
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Molecular FormulaC34H38N2O4
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Purity>98% (HPLC)
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SolubilityDMSO: 100 mg/mL (185.64 mM);Water: Insoluble
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SMILESCc1cccc(COc2ccccc2CN(CC[C@H](N)C(O)=O)Cc2ccccc2OCc2cccc(C)c2)c1
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Chemical Name(S)-2-Amino-4-(bis(2-((3-methylbenzyl)oxy)benzyl)amino)butanoic acid
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
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Histrelin acetate
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