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V9302

CAS No. 1855871-76-9

V9302( V 9302 | V-9302 )

Catalog No. M20085 CAS No. 1855871-76-9

V-9302 (V9302) is a competitive antagonist of transmembrane glutamine flux that selectively and potently targets the amino acid transporter ASCT2 (IC50: 9.6 uM).

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
Size Price / USD Stock Quantity
1 mL x 10 mM in DMSO 88 In Stock
2MG 33 In Stock
5MG 53 In Stock
10MG 77 In Stock
25MG 140 In Stock
50MG 214 In Stock
100MG 344 In Stock
200MG 505 In Stock
500MG Get Quote In Stock
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Biological Information

  • Product Name
    V9302
  • Note
    Research use only, not for human use.
  • Brief Description
    V-9302 (V9302) is a competitive antagonist of transmembrane glutamine flux that selectively and potently targets the amino acid transporter ASCT2 (IC50: 9.6 uM).
  • Description
    V-9302 (V9302) is a competitive antagonist of transmembrane glutamine flux that selectively and potently targets the amino acid transporter ASCT2 (IC50: 9.6 uM).
  • In Vitro
    V-9302 inhibits ASCT2-mediated glutamine uptake in human cells in a concentration-dependent fashion and exhibits a 100-fold improvement in potency over gamma-L-glutamyl-p-nitroanilide.Pharmacological blockade of ASCT2 with V-9302 results in attenuated cancer cell growth and proliferation, increases cell death, and increases oxidative stress.
  • In Vivo
    V-9302 (75 mg/kg; i.p.; daily fo 21 days) prevents tumor growth in both HCT-116 and HT29 xenograft models.The combination ofCB-839 and V-9302 (30 mg/kg; i.p.; SNU398 and MHCC97H cells were grown as tumor xenografts in BALB/c nude mice; for 20 or 15 d, respectively) elicits a strong growth inhibition in both SNU398 and MHCC97H xenograft models, while single-drug treatment showed modest anti-tumor effects.V-9302 (50 mg/kg ; i.p.; daily for 5 days) displays markedly reduced tumor growth. Animal Model:6-week old, female athymic nude mice (bearing HCT-116 (KRAS G13D) or HT29 (BRAF V600E) cell-line)Dosage:75 mg/kg Administration:Intraperitoneally; daily fo 21 daysResult:Prevented tumor growth.
  • Synonyms
    V 9302 | V-9302
  • Pathway
    Others
  • Target
    Other Targets
  • Recptor
    ASCT2
  • Research Area
    ——
  • Indication
    ——

Chemical Information

  • CAS Number
    1855871-76-9
  • Formula Weight
    538.69
  • Molecular Formula
    C34H38N2O4
  • Purity
    >98% (HPLC)
  • Solubility
    DMSO: 100 mg/mL (185.64 mM);Water: Insoluble
  • SMILES
    Cc1cccc(COc2ccccc2CN(CC[C@H](N)C(O)=O)Cc2ccccc2OCc2cccc(C)c2)c1
  • Chemical Name
    (S)-2-Amino-4-(bis(2-((3-methylbenzyl)oxy)benzyl)amino)butanoic acid

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1.Schulte ML et al. Pharmacological blockade of ASCT2-dependent glutamine transport leads to antitumor efficacyin preclinical models. Nat Med. 2018 Feb;24(2):194-202.
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