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SGC-GAK-1

CAS No. 2226517-76-4

SGC-GAK-1( —— )

Catalog No. M19961 CAS No. 2226517-76-4

SGC-GAK-1 is a selective cyclin G-associated kinase (GAK) inhibitor (Ki: 3.1 nM).

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
Size Price / USD Stock Quantity
1 mL x 10 mM in DMSO 45 In Stock
5MG 41 In Stock
10MG 69 In Stock
25MG 141 In Stock
50MG 221 In Stock
100MG 328 In Stock
200MG 458 In Stock
500MG Get Quote In Stock
1G Get Quote In Stock
Get Quotation Bulk Inquiry Add to Cart

Biological Information

  • Product Name
    SGC-GAK-1
  • Note
    Research use only, not for human use.
  • Brief Description
    SGC-GAK-1 is a selective cyclin G-associated kinase (GAK) inhibitor (Ki: 3.1 nM).
  • Description
    SGC-GAK-1 is a selective cyclin G-associated kinase (GAK) inhibitor (Ki: 3.1 nM).
  • In Vitro
    Cell Viability Assay Cell Line:Prostate cancer cells (22Rv1, LNCaP, VCaP, PC3, DU145) Concentration:0.1, 1, and 10 μM Incubation Time:48 hours or 72 hours Result:Showed potent antiproliferative activity in LNCaP and 22Rv1 cells with IC50s of 0.05±0.15 μM and 0.17±0.65 μM, respectively.
  • In Vivo
    ——
  • Synonyms
    ——
  • Pathway
    Others
  • Target
    Other Targets
  • Recptor
    GAK
  • Research Area
    ——
  • Indication
    ——

Chemical Information

  • CAS Number
    2226517-76-4
  • Formula Weight
    389.24
  • Molecular Formula
    C18H17BrN2O3
  • Purity
    >98% (HPLC)
  • Solubility
    DMSO: 40 mg/mL;Ethanol: 15 mg/mL
  • SMILES
    COc1cc(Nc2ccnc3ccc(Br)cc23)cc(OC)c1OC
  • Chemical Name
    6-Bromo-N-(345-trimethoxyphenyl)quinolin-4-amine

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1.Asquith CRM et al. SGC-GAK-1: A Chemical Probe for Cyclin G Associated Kinase (GAK). J Med Chem. 2019 Feb 26.
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